Abstract: Objective Pregnancy and lactation-associated osteoporosis （PLO） is a rare form of osteoporosis causing significant disability. This case could help increase awareness of the disease and accumulate the experience in diagnosis and treat. Methods The Clinical characteristics were analyzed retrospectively in a patient with PLO regard to the elaborate diagnosis and treatment. Results The PLO patient was young women, with regular menstruation, back pain and limited mobility in the early lactation. Biochemical examination was basically normal, and imaging examination showed multiple vertebral compression fractures, bone mineral density examination indicates osteoporosis. Lactation was terminated after exclusion of other osteoporosis causes and received treatment of calcium, vitamin D, calcitonin, and biphosphonates. The back pain disappeared obviously. The findings are discussed in view of the current literature. Conclusions PLO must be kept in mind in the differential diagnosis in patients presenting with low back pain during or after pregnancy. Most PLO patients have a good prognosis by stopping breastfeeding, giving calcium, vitamin D, bisphosphonates and other drugs, but they should be followed up for a long time.

Key words: pregnancy, lactation, osteoporosis, fracture

摘要： 目的 妊娠哺乳相关性骨质疏松症（PLO）是一种罕见的明显致残性疾病,通过个案分析和文献回顾以提高对本病的认识和临床应对能力。方法 回顾性分析一例PLO患者的临床特点和诊疗经过并进行相关文献复习。结果 该患者为青年女性,平素月经规律,哺乳早期出现腰痛及活动障碍,生化检查基本正常,影像学检查示椎体多发亚急性压缩性骨折,骨密度检查提示骨质疏松。排除继发性骨质疏松,诊断为PLO后停止哺乳,予以钙剂、维生素D、降钙素及双膦酸盐等治疗,腰疼痛明显减轻。结论 对于妊娠期和哺乳期出现腰背部疼痛的患者要警惕PLO可能。停止哺乳、给予钙剂、维生素D、双膦酸盐等药物,多数患者预后良好,但需长期随访。

关键词: 妊娠, 哺乳, 骨质疏松, 骨折