High cost and frequent adverse events： the future of Cabozantinib for the first-line treatment of metastatic renal cell carcinoma

doi:10.3969/j.issn.1009-976X.2021.04.003

Lingnan Modern Clinics In Surgery ›› 2021, Vol. 21 ›› Issue (04): 387-391.DOI: 10.3969/j.issn.1009-976X.2021.04.003

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High cost and frequent adverse events： the future of Cabozantinib for the first-line treatment of metastatic renal cell carcinoma

YANG Jing-ying^1,2,3, XIE Ying-wei^1,2,3, ZHU Ding-jun^1,3, XIE Wen-lian^1,2,3

1. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University;
2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University;
3. Guangdong Provincial Clinical Research Center for Urological Diseases, Guangzhou 510289, China

Contact: XIE Wen-lian, xiewl@mail.sysu.edu.cn

高昂费用及频发的不良反应：转移性肾细胞癌一线治疗用药卡博替尼的未来之路

杨晶莹^1,2,3, 谢英伟^1,2,3, 朱定军^1,3, 谢文练^1,2,3,*

1.中山大学孙逸仙纪念医院泌尿外科,广州 510289;
2.中山大学孙中山纪念医院广东省恶性肿瘤表观遗传学与基因调控重点实验室,广州 510289;
3.广东省泌尿外科疾病临床研究中心,广州 510289

通讯作者: *谢文练,主任医师,博士研究生导师,Email: xiewl@mail.sysu.edu.cn
作者简介:谢文练,教授，主任医师,博士生导师,中山大学孙逸仙纪念医院泌尿外科教授，从事泌尿外科的医教研工作30 余年。在泌尿系结石、肿瘤、前列腺增生及肾上腺肿瘤、尿道狭窄、男性泌尿生殖系畸形等疾病的诊断和治疗方面积累了丰富的临床经验，擅长腔内泌尿外科窥镜手术、腹腔镜手术、复杂性尿路结石手术开放性手术等。获得并主持多项国家自然科学基金及广东省自然科学基金。
基金资助:
广东省自然科学基金（2019A1515012199）; 广东省泌尿外科疾病临床研究中心（2020B1111170006）

Abstract

Abstract: The drug treatment of metastatic renal cell carcinoma is the focus at present. The 2020 edition of EAU guidelines of renal cell carcinoma recognizes the role of Cabozantinib for the first time and lists it as the first-line treatment for patients who cannot accept immune checkpoint inhibition treatment. This paper will elaborate the treatment mechanism, treatment scheme, treatment effect, adverse events and treatment cost of Cabozantinib, and analyze the advantages and disadvantages of Cabozantinib in detail. It will also compare Cabozantinib with sunitinib, and further explore the prospect of Cabozantinib for metastatic renal cell carcinoma.

Key words: metastatic renal cell carcinoma, Cabozantinib, sunitinib

摘要： 转移性肾细胞癌的药物治疗是目前讨论的热点,2020版EAU肾癌诊治指南首次承认了卡博替尼的作用,并将其列为不能接受免疫检查点抑制治疗患者的一线用药。本文将从卡博替尼的作用机制、治疗方案、治疗效果、不良反应及治疗的费用成本方面进行阐述,详细分析卡博替尼的优劣势,并将其与舒尼替尼进行比较,进一步探讨卡博替尼治疗转移性肾癌的前景。

关键词: 转移性肾癌, 卡博替尼, 舒尼替尼

CLC Number:

R737.11

YANG Jing-ying, XIE Ying-wei, ZHU Ding-jun, XIE Wen-lian. High cost and frequent adverse events： the future of Cabozantinib for the first-line treatment of metastatic renal cell carcinoma[J]. Lingnan Modern Clinics In Surgery, 2021, 21(04): 387-391.

杨晶莹, 谢英伟, 朱定军, 谢文练. 高昂费用及频发的不良反应：转移性肾细胞癌一线治疗用药卡博替尼的未来之路[J]. 岭南现代临床外科, 2021, 21(04): 387-391.

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High cost and frequent adverse events： the future of Cabozantinib for the first-line treatment of metastatic renal cell carcinoma

高昂费用及频发的不良反应：转移性肾细胞癌一线治疗用药卡博替尼的未来之路

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