Abstract: Objective To investigate the expression and clinical significance of integrin αv （ITGAV） in colorectal cancer. Methods Immunohistochemical method was used to detect the expression of ITGAV in 91 cases of colorectal cancer tissues and 18 cases of adjacent tissues, and the relationship between the expression of ITGAV and clinicopathological factors was analyzed. The expression of ITGAV mRNA in colorectal cancer and clinical follow up data was download from GEO and TCGA databases, and Kaplan-Meier method was used for survival analysis. Results The expression of ITGAV in colorectal cancer tissues was significantly higher than that in adjacent tissues, and the difference was statistically significant （P<0.05）. Among 91 cases of colorectal cancer, there were 61 cases in the high expression group of ITGAV and 30 cases in the low expression group. The expression of ITGAV was related to vascular nerve invasion, depth of invasion, lymph node metastasis, distant metastasis and TNM staging （P<0.05）, but not significantly related to gender, age, tumor location and degree of differentiation （P>0.05）. Survival analysis showed that the overall survival rate of patients in the high expression group of ITGAV was significantly lower than that in the low expression group （P<0.05）. Conclusion High expression of ITGAV is associated with the invasion, metastasis and poor prognosis of colorectal cancer.

Key words: integrin αv, colorectal cancer, prognosis

摘要： 目的 探讨整合素αv（ITGAV）在结直肠癌中的表达和临床意义。方法 采用免疫组织化学法检测91例结直肠癌组织及18例癌旁组织中ITGAV的表达,分析ITGAV的表达与临床病理因素的关系。利用GEO和TCGA数据库下载结直肠癌ITGAV的表达及临床随访数据进行生存分析。结果 ITGAV在结直肠癌组织中的表达显著高于癌旁组织,差异有统计学意义（P<0.05）。91例结直肠癌组织中ITGAV高表达组有61例,低表达组有30例。ITGAV的表达与脉管神经侵犯、浸润深度、淋巴结转移、远处转移及TNM分期相关（P<0.05）,与性别、年龄、肿瘤部位及分化程度无明显相关（P>0.05）。生存分析显示ITGAV高表达组患者总生存率显著低于低表达组（P<0.05）。结论 ITGAV高表达与结直肠癌的侵袭转移及预后不良相关。

关键词: 整合素αv, 结直肠癌, 预后