Abstract: Objective To observe the efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin （PA-MSHA） in the treatment of simple breast cysts, and to investigate the value of piliated pseudomonas aeruginosa in treating simple breast cysts. Methods 120 cases were divided into 3 groups, each group contained 40 cases. Cases in group A, B and C were treated with ultrasound guided suction combined with injection of PA-MSHA, ethanol and hypertonic sugar, respectively. Adverse effects of each group were observed and recorded. All cases were followed-up for about 24 months. The curative effect and side-effects of treatment were compared between the three groups. Results All cases have completed these treatments successfully. 113 patients were followed-up for about 24 months, while 7 cases were lost. There was no statistical significance difference between the three groups comparing the curative effect （P > 0.10）. Adverse effects were observed in all groups during treatment. The rate of adverse effects of group A was lower than group B and C. There was statistical significance difference between group A and the other two groups （P < 0.016）. Conclusion The ultrasound guided suction combined with injection of pseudomonas aeruginosa-mannose sensitive hemagglutinin has a prominent effect in the treatment of simple breast cysts and the adverse events are rare. The application of pseudomonas aeruginosa-mannose sensitive hemagglutinin in the treatment of simple breast cysts is valuable.

Key words: simple breast cysts, pseudomonas aeruginosa-mannose sensitive hemagglutinin, ethanol, hypertonic sugar

摘要： 目的 通过观察铜绿假单胞菌注射液（PA-MSHA）对乳腺囊肿的治疗效果,探讨PA-MSHA在单纯性乳腺囊肿治疗中的应用价值。方法 将120例单纯性乳腺囊肿患者随机分为3组,每组40例。A组于超声引导囊肿穿刺抽液后注入PA-MSHA,B组于抽液后注入无水乙醇,C组于抽液后注入高渗糖水,记录各组患者治疗期间的不良反应并随访24个月,对3组治疗期间的不良反应及治疗效果进行对比。结果 120例患者均完成治疗,其中113例完成随访,失访7例。术后6、12、24个月,各组间的治疗效果无明显统计学差异（P > 0.10）。A、B、C组治疗期间均出现不良反应,其中A组不良反应率明显低于B、C组,差异具有统计学意义（P < 0.016）。结论 超声引导下囊肿穿刺抽液后注射铜绿假单胞菌注射液可有效治疗单纯性乳腺囊肿,不良反应少,具有临床应用价值。

关键词: 单纯性乳腺囊肿, 铜绿假单胞菌注射液, 无水乙醇, 高渗糖水