Abstract: ［Abstract］ Objective To evaluate the application of modified frailty index （mFI） in predicting short-term outcomes of elderly patients undergoing laparoscopic rectal cancer surgery after neoadjuvant therapy. Methods We collected 147 elderly patients who underwent laparoscopic rectal cancer surgery after neoadjuvant therapy in Guangzhou First People′s Hospital from January 2012 to June 2018. According to the preoperative mFI score， they were divided into non-weakening group （mFI < 0.29， 106 cases） and weakening group （mFI> 0.29， 41 cases）. The demographic data， operation-related data， short-term clinical efficacy and postoperative complications of the two groups were analyzed. Statistical analysis was carried out on the indicators. Results 27.9% of patients were assessed as weak. There were significant differences in hospitalization days， post-operative complications between the weakened group and the non-weakened group（13.7±8.6 vs 10.5±3.8 d，P=0.025；20/106 vs 16/14，P=0.011）. Conclusion Excessive mFI is an important index to predict the occurrence of complications after neoadjuvant therapy for rectal cancer patients. Preoperative mFI score for elderly patients with colorectal cancer is helpful to provide a reasonable basis for clinical diagnosis and treatment and reduce the incidence of complications after surgery.

Key words: modified frailty index, postoperative complications, aged patient, laparoscopic rectal cancer surgery, neoadjuvant therapy

摘要： ［摘要］ 目的 评估改良衰弱指数（mFI）在预测新辅助治疗后行腹腔镜直肠癌手术老年患者短期疗效及肿瘤学结果中的应用。方法 收集广州市第一人民医院2012年1月至2018年6月行新辅助治疗后再行腹腔镜直肠癌手术的老年患者147例，依据患者术前mFI评分分为无衰弱组（mFI≤0.29，106例） 、衰弱组（mFI> 0.29，41例），并对两组患者在人口统计学、手术相关数据、短期临床疗效、术后并发症等指标进行统计分析。结果 27.9%的患者被评估为衰弱。衰弱组患者在住院天数、术后并发症均高于非衰弱组患者（13.7±8.6 vs 10.5±3.8 d，P=0.025；20/106 vs 16/14例，P=0.011）。结论 mFI过高是预测新辅助治疗后行直肠癌患者术后并发症发生的重要指标，术前对老年结直肠癌患者患者进行mFI评分有助于为临床诊疗提供合理依据，降低术后并发症发生率。

关键词: 术后并发症, 老年患者, 新辅助治疗, 改良衰弱指数, 腹腔镜直肠癌手术