Abstract: ［Abstract］ Objective To investigate the effects of transversus abdominis plane block with mepivacaine on hyperalgesia，which was induced by remifentanil. Methods A total of 50 patients undergoing selective abdominal hysterectomy were randomly divided into mepivacaine group or control group. In mepivacaine group， 1.5% mepivacaine 20 mL was used for transversus abdominis plane block under ultrasound guidance on each side after anesthesia induction， whereas no transversus abdominis plane block was performed in control group. The anesthesia was maintained with sevoflurane at 0.8?1.1MAC and remifentanil at 0.05~0.3 μg/kg·min， which was adjusted depending on the hemodynamic changes and Bispectral index （BIS）. The total intraoperative consumption of remifentanil， the degrees of postoperative pain using visual analogue score （VAS score） at 1 h（VAS 1）， 3 h（VAS2）， 6 h（VAS3）， 12 h（VAS4）， and 24 h （VAS 5） after surgery， as well as the frequency of analgesics supplement and related complications were observed and compared. Results The intraoperative consumption of remifentanil in mepivacaine group was significantly lower than that in control group （P<0.05）， as well as the VAS score at each time point （P<0.05）. And the frequency of postoperative analgesics supplementation was also less than that in control group （P<0.05）. Conclusion Pretreatment of transversus abdominis plane block with mepivacaine can significantly reduce the consumption of intraoperative remifentanil， resulting in relieving hyperalgesia caused by remifentanil.

Key words: hyperalgesia, mepivacaine, remifentanil, transversus abdominis plane block

摘要： ［摘要］ 目的 观察甲哌卡因腹横筋膜阻滞对瑞芬太尼引起的痛觉超敏反应的影响。方法 收集择期下行腹式全宫手术患者50例，分为甲哌卡因组（25例）和对照组（25例）。甲哌卡因组在麻醉诱导后在超声引导下用1.5%甲哌卡因行腹横筋膜阻滞，每侧20 mL，对照组不予腹横筋膜阻滞。麻醉维持均采用七氟烷0.8-1.1 MAC，瑞芬太尼0.05~0.3 μg/kg·min，监测脑电双频指数（BIS），根据BIS值和血流动力学情况调整麻醉用药。观察并比较患者术中瑞芬太尼总的消耗量，术后1 h（VAS 1），3 h（VAS 2），6 h（VAS 3），12 h（VAS 4），24 h（VAS 5）的视觉模拟评分（VAS评分），术后病房镇痛药物的追加量及相关并发症。结果 甲哌卡因组术中瑞芬太尼用量显著小于对照组（P<0.05），术后各时间点VAS评分小于对照组（均P<0.05），而术后镇痛药物追加次数小于对照组（P<0.05）。结论 术前使用甲哌卡因腹横筋膜阻滞可明显减少术中瑞芬太尼用量，减轻瑞芬太尼引起的痛觉超敏反应。

关键词: 甲哌卡因, 瑞芬太尼, 腹横筋膜阻滞, 痛觉超敏