Abstract: ［Abstract］ Objective To investigate the curative effect of arthroscope combined with sodium glassate and Glucosamine sulfate in the treatment of knee osteoarthritis （KOA）. Methods Seventy?eight patients with knee osteoarthritis were included in this study from January 2017 to March 2018. They were randomized into experimental group and control group. The patients （n=39） in experimental group underwent the management of arthroscope combined with sodium glassate and glucosamine sulfate， and the controls （n=39） was treated with arthroscopic surgery alone. Both groups were guided to perform knee functional exercise after surgery. VAS pain quantification score， Lequesne index and arthritic effect scale （AIMS） score were recorded and compared between the two groups before treatment， 2 weeks and 8 weeks after treatment. The clinical efficacy in two groups was analyzed， and the adverse reactions during the treatment were observed and recorded. Results In the experimental group and control group， there were significant differences in VAS score， Lequesne index and AIMS score before and 2 week and 8 week after treatment （all P values <0.05）. And as compared with control group， VAS score， Lequesne index and AIMS score in the experimental group showed significant differences in each time point （all P values <0.05）. Conclusion The joint arthroscope combined with sodium glassate and Glucosamine sulfate has a good effect on KOA and is superior to the single arthroscopic operation.

Key words: joint arthroscope, knee osteoarthritis, sodium vitreate, clinical efficacy, glucosamine sulfate

摘要： ［摘要］ 目的 探讨关节镜联合玻璃酸钠、硫酸氨基葡萄糖治疗膝关节炎（KOA）的疗效。方法 选取2017年1月至2018年3月拟行关节镜手术治疗的膝关节骨关节炎患者78例，随机分为试验组和对照组，试验组行关节镜联合玻璃酸钠、硫酸氨基葡萄糖治疗，对照组行关节镜手术治疗，两组术后均指导行膝关节功能锻炼。采用VAS疼痛量化评分、Lequesne指数及关节炎影响测定量表（AIMS）评分对两组患者治疗前、治疗后2周、8周的疗效进行比较分析，同时观察记录治疗过程中的不良反应。结果 组内比较，两组患者各自在治疗前后的VAS评分、Lequesne指数及关节炎AIMS评分比较，差异均具有统计学意义（P<0.05）；两组治疗后VAS评分、Lequesne指数及关节炎AIMS评分比较，术后8周时差异有统计学意义（P<0.05）；结论 关节镜联合玻璃酸钠、硫酸氨基葡萄糖治疗KOA具有良好近期疗效，优于单用关节镜手术治疗者。

关键词: 玻璃酸钠, 硫酸氨基葡萄糖, 膝骨关节炎, 临床疗效, 关节镜