Abstract: ［Abstract］ Objective To investigate the effect of the consistency between preoperative needle biopsy and classification surgical specimens on the treatment of early breast cancer. Methods Forty?eight patients with breast tumors treated with surgical operation in our hospital were selected as the research subjects. Puncture biopsy and surgical resection biopsy were carried out on all the patients above. The immunohistochemical results of ER， PR， HER2 and Ki?67 in puncture tissues were analyzed according to the standard of surgical resection biopsy. Results Forty?two cases were positive and 6 cases were negative by surgical resection. The positive predictive values of ER， PR， HER2 and Ki?67 in puncture tissues were 97.44%， 93.75%， 89.65% and 92.59%， the negative predictive values were 55.56%， 25%， 15.79% and 19.05%， the sensitivity was 92.86%， 71.43%， 61.91% and 47.62% and the specificity was 75%， 33.33%， 27.27% and 21.43%. Conclusion The combined detection of ER， PR， HER2 and Ki?67 by immunohistochemistry in puncture biopsy can accurately reflect the histopathology of breast cancer and provide a reference for the treatment of breast cancer.

Key words: estrogen receptor, breast cancer, puncture biopsy, progesterone receptor, human epidermal growth factor receptor 2

摘要： ［摘要］ 目的 探讨术前针刺活检与手术标本分类的一致性对早期乳腺癌治疗的影响。方法 以我院48例接受手术的乳腺肿瘤患者作研究对象，上述患者均接受穿刺活检和手术切除活检，以手术切除活检为标准，分析穿刺组织ER、PR、HER2和Ki?67免疫组化检测结果。结果 手术切除确诊42例阳性，6例阴性，穿刺组织ER、PR、HER2和Ki?67的，阳性预测值97.44%、93.75%、89.65%和92.59%，阴性预测值55.56%、25%、15.79%和19.05%，敏感度92.86%、71.43%、61.91%和47.62%，特异度75%、33.33%、27.27%和21.43%。结论 穿刺活检ER、PR、HER2和Ki?67免疫组化联合检测比较准确反映乳腺癌组织病理情况，为该病的治疗提供参考。

关键词: 人类表皮生长因子受体2, 穿刺活检, 雌激素受体、孕激素受体, 乳腺癌