Abstract: Objective To investigate the expression of PPARγ coactivator 1α（PGC1α）in gastric cancer and its clinical significance. Methods Ninety?nine cases of gastric cancer with the availability of clinical information and follow?up data were selected to detect PGC1α expression by immunohistochemistry，and the correlations of PGC1α expression with gastric cancer clinicopathological status as well as survival were analyzed. Results The PGC1α expression of gastric cancer was closely associated with tumor invasion，lymph node metastases，pathological TNM stage，histological type and Borrmann type（P<0.05），while recurrence，metastasis，tumor size，sex and gender was not（P>0.05）. Cox proportional hazard model applied for multivariate survival analysis revealed that PGC1α expression was an independent prognostic factor for both OS and RFS（P=0.009 and P=0.024，respectively），which is paralleled with pTNM stage，recurrence. Conclusion High PGC1α expression was identified as a protective prognostic factor for both OS and RFS in gastric cancer.

Key words: PPARγ coactivator 1α, prognosis, gastric cancer

摘要： 目的 探讨过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC1α）在胃癌组织中的表达情况及其临床意义。方法 选取随访资料完整的99 例胃癌组织标本，利用免疫组化技术检测胃癌组织中PGC1α的表达情况，并分析 PGC1α表达与临床病理特征之间的关系及对生存预后的影响。结果 PGC1α在胃癌患者中的表达水平与肿瘤浸润深度、淋巴结转移、pTNM 分期、组织分化程度及 Borrmann 分型密切相关（P<0.05），而与复发、肿瘤大小、远处转移、性别及年龄无关（P>0.05）。COX 回归分析结果显示 PGC1α的表达水平与总生存预后（OS）及无复发生存预后（RFS）密切相关，差异具有统计学意义（P=0.024），是胃癌患者预后的独立预测因素。结论PGC1α的表达水平与胃癌患者OS 和RFS 明显相关，其高表达是胃癌患者预后的独立保护因素。

关键词: PPARγ辅激活因子1α, 胃癌, 预后