Abstract: ［Abstract］ Objective To explore the clinical efficacy of rapamycin in the treatment of hemangiomas in patients who have failed propranolol treatment. Methods From January 2016 to January 2018，40 cases of propranolol in the outpatient clinic in the People s Hospital of Puning failed to be used for treatment. Children with hemangiomas are treated with rapamycin（total daily dose 0.1 mg/kg，once daily or divided into two doses daily for half?time use，3 months for a single course of treatment），and the size of the hemangiomas is observed and recorded. Color change and related side effects were used to evaluate its efficacy and safety. Results The effective rate was 92.5% in one month and 94.4% in three months. The related side effects were light and controllable. Conclusion Rapamycin is effective and has fewer side effects in children with hemangiomas who are refractory to propranolol.

Key words: infants, efficacy, rapamycin, hemangioma

摘要： ［摘要］ 目的 探究雷帕霉素对普萘洛尔治疗无效的血管瘤患儿临床疗效分析。方法 从2016 年1 月～2018 年1 月在普宁市人民医院门诊的 40 例普萘洛尔治疗无效的血管瘤患儿，接受雷帕霉素治疗（每日总量 0.1 mg/kg，每日一次或分为每日两次每次半量使用，3 个月为单个疗程），观察记录血管瘤大小、颜色变化和相关副作用，以评价其疗效和安全性。结果 服药1 个月有效性为为92.5％，3 个月有效性为94.4％，相关副反应较轻且可控。结论 雷帕霉素对对普萘洛尔治疗无效的血管瘤患儿疗效显著、副作用少。

关键词: 血管瘤, 雷帕霉素, 疗效, 婴幼儿