Abstract: ［Abstract］ Hepatocellular carcinoma（HCC）is one of the common malignant tumors in China. In recent years, the incidence of liver cancer and mortality have increased year by year, and postoperative recurrence and metastasis are considered to be the leading cause of death in patients with liver cancer. As a research hotspot of liver cancer in recent years, circulating tumor cells（CTCs）have been proposed as real?time and noninvasive monitoring of the changes of liver cancer patient s condition, which can be better assessment of postoperative prognosis of liver cancer and develop individualized treatment options. This article reviews the current status of circulating tumor cells in hepatocellular carcinoma in recent years.

Key words: hepatocellular carcinoma, biomarker, circulating tumor cell, prognosis

摘要： ［摘要］原发性肝癌是我国常见的恶性肿瘤之一，近年来肝癌的发病率及死亡率都有逐年上升的趋势，而术后的复发与转移被认为是导致肝癌患者死亡的主因。循环肿瘤细胞（circulatingtumorcell，CTC）作为近年来肝癌研究热点，它能实时、无创的监测肝癌患者病情变化，并较好的评估肝癌术后预后及制定个体化治疗方案。本文就循环肿瘤细胞在近年来肝癌中的研究现状做一综述。

关键词: 生物标志物, 肝癌, 循环肿瘤细胞, 预后