Abstract:

Objective To observe the changes of serum resistin level in patients with gastric cancer associated-cachexia and to investigate the relationship between resistin and interleukin-6（IL-6）. Methods Twenty-three cases of gastric cancer patients with cachexia were assigned to the cachexia group; 23 cases of gastric cancer patients without cachexia were used as the gastric cancer group; and 23 healthy people were taken as normal controls. All the subjects were tested the sex, age, BMI and pathologic stages of cancer. The serum levels of IL-6, resistin were detected by enzyme-linked immunoabsorbent assay （ELISA）. Results Patients with pathologic stages Ⅲ and Ⅳwere more susceptible to cachexia than those with pathologic stages Ⅰ and Ⅱ in gastric cancer（P< 0.05）. Compared with control group, the serum resistin level and IL-6 were significantly increased in the cathexia group and gastric cancer group（P<0.05）. Along with pathological stage increasing, the serum resistin level were significantly increased. Serum resistin level was positive correlated with IL-6 in the cachexia group（r = 0.512, P = 0.012）. Conclusion Along with pathological stage increasing in gastric cancer, the serum levels of resistin and IL-6 were significantly increased. Serum resistin and IL-6 were increased in the cathexia patients. And serum resistin was positively correlated with interleukin-6 in gastric cancer cachexia.

Key words: resistin, IL-6, gastric cancer, cachexia

摘要：

目的 观察血清抵抗素与胃癌及胃癌恶病质的关系，并初步探讨胃癌恶病质中抵抗素与白介素-6相关性。方法 选取胃癌并恶病质患者23例为胃癌恶病质组，胃癌患者23例为胃癌组、健康成人23例为对照组。记录患者性别、年龄、BMI及肿瘤分期。采用ELISA法测定血清抵抗素和白介素-6水平（IL-6）。结果 Ⅲ、Ⅳ期胃癌较Ⅰ、Ⅱ期胃癌更易发生恶病质（P<0.05），与健康成人相比血清抵抗素、白介素-6在胃癌及胃癌恶病质中升高（P<0.05）。血清抵抗素水平随着胃癌病理分期的增加有逐渐升高趋势（P<0.05）。胃癌恶病质组血清白介素-6水平与血清抵抗素水平显著正相关（r=0.512，P=0.012）。结论 血清抵抗素水平随着胃癌病理分期的增加逐渐升高，胃癌恶病质患者血清抵抗素的升高与白介素-6呈正相关关系。

关键词: 胃癌, 恶病质, 白介素-6 , 抵抗素