Abstract:

 Objective To investigate the effect of different oxygen flow rate on airway surface anesthesia with nebulized lidocaine. Methods Seventy-five patients with difficult airways undergoing awake tracheal intubation, in accordance with the random number table, were divided into 3 groups（n= 25 each）. Patients in all groups inhaled 2% lidocaine 10 ml for airway surface anesthesia, but the oxygen flow rate between three groups was different. The oxygen flow rate was 3 L/min in group A, 6 L/min in group B and 9 L/min in group C. Awake tracheal intubation guided by fibrotic bronchoscope was performed at the end of inhalation. The intubation condition and the tolerance to tube were assessed, success rate and time of intubation, together with adverse effects and complications were recorded. Results The intubation condition and the tolerance to tube of group B was significantly better than that in group A and group B（Ρ <0.05）. The first-attempt success rate and time of intubation in group B were significantly higher than that in group A and group C（Ρ <0.05）, and there was no significantly difference between group A and group C. Conclusion The effect of airway surface anesthesia by inhaling quantitative lidocaine for awake tracheal intubation was better when the oxygen flow rate was 6 L/min.

Key words: oxygen flow rate, lidocaine, nebulized inhalation, airway surface anesthesia

摘要：

目的 探讨不同的氧气流量对雾化吸入2%利多卡因进行气道表面麻醉效果的影响。方法 选择需行清醒气管插管的困难气道患者75例，按随机数字表法分为A、B、C三组（n=25），所有患者都通过氧气驱动雾化吸入2%利多卡因10mL的方法进行气道黏膜表面麻醉，但A、B、C三组患者所用的氧气流量分别为3L/min、6L/min、9L/min，雾化吸入结束后使用纤支镜引导进行气管插管。评估记录插管条件和导管耐受性；记录气管插管首次成功率、总成功率、插管时间；记录不良心血管反应和并发症发生情况。结果 与A组和C组比较，B组的插管条件、导管耐受性更好，气管插管首次成功率更高，插管时间更短（Ρ<0.05）；A、C两组间比较，无明显差异。结论 在清醒气管插管过程中定量雾化吸入2%利多卡因进行气道粘膜表面麻醉时，氧气流量为6L/min的效果更好。

关键词: 利多卡因, 氧气流量, 雾化吸入 , 气道表面麻醉