Abstract:

 Objective To investigate the expression of p300/CBP in papillary thyroid carcinoma and its clinical significance. Methods Immunohistochemical technique was performed to detect the expression of p300/CBP in papillary thyroid carcinoma tissues and normal thyroid tissues, and the relationship between the CBP expression and clinicopathological factors was analyzed. Results The expression level of p300/CBP was increased in papillary thyroid carcinoma tissues when compared with normal thyroid tissues. However, no association was found between p300/CBP expression and clinicopathological factors or prognosis. Multivariate analysis Results showed that age and distant metastasis were independent prognosis factors for patients with papillary thyroid carcinoma. Conclusion Up-regulation of p300/CBP was detected in papillary thyroid carcinoma tissues, but it has no influence on prognosis.

Key words: P300/CBP, prognosis, papillary thyroid carcinoma

摘要：

目的 探讨组蛋白乙酰转移酶分子p300/CBP在甲状腺乳头状癌中的表达及其临床意义。方法 利用免疫组化技术检测142例甲状腺乳头状癌组织及22例正常甲状腺组织中p300/CBP蛋白表达情况，并分析其与临床相关因素的关系。结果 p300/CBP蛋白在甲状腺乳头状癌组织中表达水平升高，但与患者性别、年龄、病理分期、T分期、N分期、M分期、复发均无关。Cox多因素分析显示年龄和远处转移是影响甲状腺乳头状癌预后的独立因素。结论 本研究显示p300/CBP蛋白在甲状腺乳头状癌组织中存在高表达，但没有发现与甲状腺乳头状癌的预后有关。

关键词: 甲状腺乳头状癌, P300/CBP, 预后