Abstract: 【Abstract】 Objective The neutrophil lymphocyte ratio（NLR）was used as a easy parameter of systemic inflammation and immune status. The purpose was to investigate the clinical importance of preoperative NLR in patients with breast cancer. Methods We performed a retrospective analysis of 213 eligible patients diagnosed with primary breast cancer following radical surgery at Chancheng District Central Hospital of Foshan City. Clinicopathological parameters and survival status were investigated. The optimal cut?off value for NLR was obtained by receiver operating characteristics（ROC）analysis. Overall survival（OS）and disease?free survival（DFS）were assessed using the Kaplan?Meier method. Univariate and multivariate Cox regression model was performed to evaluate clinical parameters for their prognostic relevance. Results The optimal cut?off value was determined as 2.2 for NLR. Significant distribution differences were observed between the two groups in terms of histological grade,T stage,TNM stage. Patients in the elevated group（NLR≥2.2）showed significantly lower OS（5?year OS：59.6% vs 78.9%, P=0.001）and DFS（5?year DFS：56.7% vs 78.0%，P=0.002）. In addition，histological grade，T stage， NLR status and T stage,NLR status were independent prognostic factors for OS and DFS in our study respectively. Conclusion Our study suggested that preoperative NLR indicated poorer OS and DFS in patients with breast cancer following radical surgery. Further studies were required before it can be used for individual risk assessment.

Key words: overall survival, breast cancer, neutrophil lymphocyte ratio, disease?free survival

摘要： 【摘要】目的 中性粒细胞淋巴细胞百分比（NLR）是一项简单检测全身炎症反应和免疫状态的指标。本研究旨在探讨NLR对乳腺癌患者的临床意义。方法 回顾性分析213例在佛山市禅城区中心医院接受根治手术的乳腺癌患者，分析其临床病例特点及生存预后。NLR的最佳截点采用受试者工作特征曲线（ROC）分析，采用Kaplan?Meier法分析总体生存（OS）与无病生存（DFS），单因素及多因素Cox回归模型用于评估各临床因素与预后的相关性。结果 本组研究NLR最佳的截点是2.2。两组患者在组织分级、T分期、TNM分期之间的分别上无统计学差异。高NLR组（NLR≥2.2）的OS（5年OS分别为59.6%和78.9%，P=0.001）及DFS（5年DFS分别为56.7%和78.0%，P=0.001）较差。此外，影响OS的独立预后因素分别为组织分级、T分期和NLR，而组织分级、T分期和NLR是影响DFS的独立预后因素。结论 术前NLR升高对于接受根治手术的乳腺癌患者提示总体预后及无病生存期较差。但其运用于个体化危险评估尚需未来更多的临床研究。

关键词: 中性粒细胞淋巴细胞百分比, 乳腺癌, 总体生存, 无病生存