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Lingnan Modern Clinics in Surgery ›› 2016, Vol. 16 ›› Issue (06): 747-750.DOI: 10.3969/j.issn.1009-976X.2016.06.028

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Advance in study of microRNA in invasion and metastasis of thyroid carcinoma

LIN Zaikai,MA Baojin   

  • Contact: MA Baojin

microRNA 与甲状腺癌侵袭转移关系的研究进展

林在楷 马保金   

  1. 上海市静安区中心医院普外科
  • 通讯作者: 马保金

Abstract: 【Abstract】 To summarize the relationship of microRNA(miRNA)to metastasis and invasion of thyroid cancer. Domestic and international publications involving the relationship of miRNA to thyroid cancer were screened and reviewed. miRNA played a key role in the process of thyroid cancer metastasis. According to its function, it could be distinguished from cancer-promoting gene(such as miR-221, miR-222, miR-146b, etc. )to suppressor gene(such as miR-199a, miR-204, etc. ). The more detailed experimental studies about the relationship of miRNA to metastasis and invasion of thyroid cancer need to be researched in order to provide a new method for the diagno sis and treatment of thyroid cancer metastasis and invasion.

Key words: Metastasis, MicroRNA, Invasion, Thyroid cancer

摘要:

总结microRNA(miRNA)与甲状腺癌侵袭、转移关系的研究进展。检索并筛选近年来国内外发表的有关miRNA与甲状腺癌侵袭、转移关系的文献并对其进行综述。研究表明许多miRNA在甲状腺癌发生、发展与侵袭、转移过程中都起着关键作用,按其作用可分为促癌miRNA(miR-221、miR-222、miR-146b等)和抑癌miRNA(miR-199a、miR-204等)两类。因此,miRNA调控甲状腺癌侵袭及转移的具体过程还需要更多、更详细的研究。

关键词: 侵袭, 甲状腺癌, 转移, microRNA

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