Abstract: 【Abstract】 Objective To investigate the effect of preoperative arterial infusion chemotherapy with embolism on locally advanced breast cancer. Methods Thirteen patients with locally advanced breast cancer diagnosed by the core needle biopsy from February 2010 to March 2015 in this hospital were selected. Seldinger procedure was used to perform angiography by arterial femoralis. Super-selective arterial catheterization was performed to ensure the locally infusion of Epirubicin 100 mg, Mitomycin 10 mg, 5-FU 1 g plus Oxaliplatin 1 g, finally the tumor blood supply artery war embolizated. Results Of 13 cases, two patients achieved CR, ten patients achieved PR, one patient achieved SD. The rate of CR+PR was 92.3% and CR + PR + SD was 100% . All the 13 patients received radical mastectomy. Conclusion Preoperative arterial infusion chemotherapy is effective and safe in the treatment of locally advanced breast cancer.

Key words: Locally advanced breast cancer, Preoperative chemotherapy, Arterial infusion chemotherapy

摘要： 【摘要】目的评价术前介入化疗治疗局部晚期乳腺癌的近期疗效。方法选取我科2010年2月至2016年1月期间经空心针穿刺活检病理证实的局部晚期乳腺癌患者共13例，全部采用Seldinger’s方法，局麻后经股动脉穿刺，将导管选择至肿瘤主要供血动脉，灌注化疗药物，方案为法玛新100 mg，丝裂霉素10 mg，氟尿嘧啶1000 mg，奥沙利铂150 mg，随后选择性栓塞供血动脉。结果CR2例，PR10例，SD1例，有效率（CR+PR）为92.3%，患者获益率（CR+PR+SD）为100%。13例患者均获得根治性切除。结论术前介入化疗是提高局部晚期乳腺癌手术切除率有效安全的方法。

关键词: 介入治疗, 术前治疗, 局部晚期乳腺癌