Abstract: 【Abstract】〓Objective〓To investigate the effect of continuous regional artery perfusion (CRAI) on treating acute severe lipid-induced pancreatitis. Methods〓Forty-three patients with severe lipid-induced pancreatitis patients admitted to our hospital from January 2013 to May 2016 were assigned to two groups, CRAI group (n=23) and control group (n=20). The patients of CRAI group received conventional treatment combined with conventional treatment and controls were performed the conventional treatment protocol alone. The levels of white blood cell count, amylase, blood sugar, blood calcium were collected in two groups and compared between two groups. The abdominal pain relief time, serum amylase recovery time, the hospitalization stay and expenses, peripancreatic infection incidence of pancreatic pseudocyst were compared between two groups. Results〓In CRAI group, the levels of serum amylase, urinary amylase, blood glucose on the sixth day, the first ten days of recovery were faster back to normal than that in conventional group, so did the blood calcium recovery time. Abdominal pain relief time, hospitalization stay, incidence of infection, pancreatic pseudocyst, pancreatic drainage in CRAI group were decreased than in normal group. Two cases were dead in control group and there were no death in CRAI group. Conclusion〓In the present study, CRAI was demonstrated a good efficacy in the treatment of severe acute pancreatitis, selected as an alternative treatment plan in combination with treatment protocol.

Key words: Acute pancreatitis, Interventional therapy, Intraartery infusion, Lipid-induced

摘要： 【摘要】〓目的〓评价经供胰腺血管留置导管持续灌注疗法(CRAI)治疗重症脂源性胰腺炎的疗效。方法〓选择2013年1月至2016年5月期间纳入的43例患者重症脂源性胰腺炎患者,包括区域灌注组(23例)和常规治疗组(20例),分析对比白细胞计数﹑血清淀粉酶﹑尿淀粉酶﹑APACHE-Ⅱ、血糖值﹑血钙值变化情况;比较两组患者腹痛缓解时间﹑血清淀粉酶恢复时间﹑总住院天数,总治疗费用;经不同治疗后,两组患者胰腺及胰周感染胰腺假性囊肿的发生率;对两组临床效果效率进行评价。结果〓血清淀粉酶、尿淀粉酶、血糖、血钙水平以及APACHE-Ⅱ评分第六天、第十天的恢复结果,区域灌注组优于常规组(P<0.05),血淀粉酶恢复时间7.2±1.6 d,区域灌注组优于常规组,腹痛缓解时间3.1±1.3 d,区域灌注组优于常规组(P<0.05)。接受区域灌注治疗的患者的平均住院时间明显缩短,腹膜后感染、胰腺假性囊肿、行胰肠内引流手术例数明显低于常规组,总临床效果好于常规组(P<0.05)。结论〓区域灌注在治疗重症急性胰腺炎方面有其优势,可结合其他手段作为针对坏死性胰腺炎的联合治疗方案。

关键词: 动脉内灌注, 介入治疗, 脂源性, 胰腺炎