Abstract: 【Abstract】〓Objective〓To investigate the efficacy and safety of oxycodone hydrochloride injection combined with propofol or sufentanil in patients underwent esophageal gastric varices (EGV) ligation operation. Methods〓Forty-eight patients with EGV were divided into two groups (n=24 each), oxycodone hydrochloride injection group (group A) and sufentanil injection group (group B). Patients in group A were administrated in vein with 0.1 mg/kg of oxycodone, induced with propofol 2 mg/kg and maintained with 4-7 mg-1·kg-1·h-1 propofol. Patients in group B were administrated in vein with 1 μg/kg of sufentanil, induced with 2 mg/kg of propofol and maintained with 4-7 mg-1·kg-1·h-1 of propofol. MAP, HR, RR, SPO2, BLS were continuously monitored. Cough, respiratory depression, total dosage of propofol and postoperative 30 min pain score were recorded. Results〓There were no significant differences in MAP, HR, RR, SPO2 and BLS between two groups (all P values were more than 0.05). The rates of adverse effects such as cough, body movement, respiratory depression, total dosage of propofol and postoperative 30 min pain score in group A were significantly lower than that of group B (P<0.05). Conclusion〓In the present study, xycodone hydrochloride injection was a safer and more effective treatment in patient underwent EGV ligation operation.

Key words: Endoscopy, Oxycodone hydrochloride injection, Esophageal gastric varices, Sufentanil injection

摘要： 【摘要】〓目的〓评价盐酸羟考酮注射液与舒芬太尼复合丙泊酚用于肝硬化食管胃底静脉曲张患者内镜下套扎治疗的效果及安全性。方法〓48例肝硬化食管胃底静脉曲张拟行内镜下套扎治疗的患者,分为羟考酮注射液复合丙泊酚组(A组)和舒芬太尼复合丙泊酚组(B组),每组24例。A组静脉注射羟考酮注射液0.1 mg/kg,丙泊酚2 mg/kg诱导,后以丙泊酚4~7 mg·kg-1·h-1维持;B组注射舒芬太尼1 μg/kg,丙泊酚2 mg/kg诱导,后以丙泊酚4~7 mg·kg-1·h-1维持。观察两组患者不同时间点的平均动脉压(MAP)、心率(HR)、呼吸频率(RR)、血氧饱和度(SpO2)和麻醉深度(BIS);记录呛咳、体动次数、丙泊酚总用量、呼吸抑制及术后30 min疼痛评分。结果〓两组各时间段MAP、HR、RR及SpO2差异无统计学意义(P>0.05),A组发生呛咳、体动、呼吸抑制发生的总例数少于B组(P<0.05),同时,A组中丙泊酚用量及术后30 min疼痛评分的概率明显低于B组。结论〓盐酸羟考酮注射液复合丙泊酚麻醉下行内镜食管胃底曲张静脉套扎,对循环和呼吸系统影响小,不良反应较少,镇痛作用持久,麻醉效果好。

关键词: 舒芬太尼注射液, 食管胃底静脉曲张, 内镜, 盐酸羟考酮注射液