Abstract: 【Abstract】〓Objective〓To investigate the clinical value of different PSA-related tumor markers in prostate cancer. Methods〓A retrospective clinical data were analyzed in 300 cases of suspected prostate cancer patients in Zhongshan Traditonal Chinese Medical Hospital from January 2011 to December 2014. According to the results of transrectal prostate biopsy, the patients were divided into two groups, prostate cancer group (n=84) and non-prostate cancer (212). The levels of F-PSA/T-PSA, PSAD and (F-PSA T-PSA)/PSAD were compared between two groups and assessed the diagnostic value of these indicators. Results〓The results of F-PSA/T-PSA, PSAD and (F-PSA/T-PSA)/PSAD showed statistically significant differences between two groups (P<0.05). (F-PSA/T-PSA)/PSAD showed the highest specificity for the diagnosis of prostate cancer in all of parameters (P<0.05). Conclusion〓in the present study, the high level of (F-PSA/T-PSA)/PSAD has diagnostic significance for early prostate cancer and showed high specificity.

Key words: PSA, Tumor markers, Prostate cancer, Diagnosis

摘要： 【摘要】〓目的〓探讨不同血清前列腺特异抗原(PSA)相关肿瘤标志物在前列腺癌中的临床价值。方法〓回顾我院2011年1月至2014年12月入院治疗的300例疑似前列腺癌患者的临床资料。上述患者入院后经直肠实施前列腺穿刺活检术后,将患者分为前列腺癌与非前列腺癌两组,其中前列腺癌88例,非前列腺癌212例(前列腺增生138例,前列腺炎78例)。对比两组患者的F-PSA/T-PSA、PSAD与(F-PSA/T-PSA)/PSAD水平,评估上述指标对于前列腺癌的诊断价值。结果〓两组患者检测F-PSA/T-PSA、PSAD与(F-PSA/T-PSA)/PSAD结果显示,组间差异具统计学意义(P<0.05)。不同PSA指标相同敏感度情况下,(F-PSA/T-PSA)/PSAD对于前列腺癌的诊断特异性最高,差异具统计学意义(P<0.05)。结论〓PSA相关肿瘤标志物检测中,(F-PSA/T-PSA)/PSAD的水平变化对前列腺癌早期诊断具较高特异性。

关键词: PSA, 肿瘤标志物, 前列腺癌, 诊断