Abstract: 【Abstract】〓Objective〓To study the curative effect, prognosis and survival conditions of early breast cancer under the age of 35 with breast-conserving surgery and modified radical operation. Methods 110 cases of early breast cancer patients in our hospital after surgical treatment were included in the study and divided into breast-conserving surgery group (61 cases) and modified radical operation group (49 cases) according to the surgical procedures. The preoperative conditions, exterior effect, long-term efficacy and quality of life of the two groups were observed and compared. Results〓The operation time,.intraoperative blood loss and hospital stay of breast-conserving surgery group were significantly decreased than that of modified radical operation group,.and the postoperative complications and the rate of good appearance were obviously improved than the modified radical group..There was no significant difference in three years relapse-free survival rate and survival period between the two groups..The SF-36 quality score of breast-conserving surgery group was higher than that of modified radical operation group. Conclusion〓For early breast cancer patients under the age of 35,.breast-conserving surgery was cosmetic,.small trauma,.fewer complications and survival as well as good quality, and can keep the similar to the traditional way of survival,.but it remains to be further confirmed with multicenter and large sample research.

Key words: Early breast cancer, Breast-conserving surgery, Modified radical operation

摘要： 【摘要】 目的 分析并比较35岁以下早期乳腺癌患者保乳术与改良根治术的疗效、预后和生存情况。方法 选择本院经手术治疗的早期乳腺癌患者110例作为观察对象,按接受手术方法的不同分为保乳术组61例和改良根治术组49例,对比观察两组患者的围手术期情况、外观疗效、长期疗效和生存质量情况。结果〓保乳术组患者手术时间、术中出血量和住院时间均较改良根治术组显著性减少(P<0.001),且术后并发症发生情况也较改良根治术组明显改善(P<0.05);保乳术组患者术后外观优良率较改良根治术组有显著性提高(P<0.05);两组患者3年无复发生存率和生存期比较无显著性差异(P>0.05);保乳术组患者3年后SF-36生存质量各项评分显著性高于改良根治术组(P<0.05)。结论〓对于35岁以下早期乳腺癌患者而言,保乳手术具有美容佳、创伤小、并发症少和生存质量好等优点,且能保持与传统方式相似的生存率,为临床治疗方法选择提供了一定的理论依据,但尚待多中心、大样本研究进一步证实。

关键词: 早期乳腺癌, 保乳手术, 改良根治术