Abstract: 【Abstract】〓Objective〓To investigate the effects of Nimotop on chronic post-traumatic hydrocephalus (CPTH) in the patients with ventriculo-peritoneal shunt (VPS). Methods〓Total 38 cases were randomized into Nimotop group and control group, each group contained 19 cases. All the patients underwent VPS treatment. Patients in the observation group was given Nimotop and those in the control group received the conventional treatment. Both group received Mini Mental State Examination (MMSE) and Barthes Index (BI) to assess quality of life and recognition. Results〓The scores of MMSE and BI increased significantly in Nimotop group after treatment, when compared with those before treatment. And the scores were higher than control group (P<0.05). No severe complications were observed of two groups. Conclusion〓VPS associated with Nimotop could ameliorate the quality of life and recognition of patients with CPTH.

Key words: Chronic post-traumatic hydrocephalus, Ventriculo-peritoneal shunt, Nimotop　

摘要： 【摘要】〓目的〓探讨脑室腹腔分流术联合尼莫同治疗外伤后脑积水的临床疗效。方法〓38例慢性外伤后脑积水患者随机分成尼莫同组和对照组各19例。对照组行脑室腹腔分流术治疗,尼莫同组在此基础上给予尼莫同治疗。所有患者均在术前和术后1月进行简易精神状态量表(MMSE)和巴氏指数(Barthel index,BI)评分,评估患者生活质量和认知功能。结果〓尼莫同组MMSE评分和BI评分增加明显,且优于对照组,差异有统计学意义(P<0.05),未观察到严重不良反应。结论〓脑室腹腔分流术联合尼莫同治疗可改善慢性外伤后脑积水患者生活质量和认知功能。

关键词: 慢性外伤后脑积水, 脑室腹腔分流, 尼莫同