Research progress of nerve lengthening approach in repairing peripheral nerve defect

doi:10.3969/j.issn.1009-976X.2014.06.026

Abstract

Abstract: 【Abstract】〓Severe peripheral nerve injury is often accompanied with a long segment of peripheral nerve defect..This is a difficult problem for surgeons to repair peripheral nerve lesions..The autologous nerve grafting is a commonly used and is a traditional surgical method to repair peripheral nerve lesions with a long segment defect..However,.the surgical neural repair approach has a poor result..Recent clinical research has focused on nerve lengthening and its postoperative changes in histology and electrophysiology..Just like distraction osteogenesis,.the surgical method works by dragging nerve in order to lengthen nerve.

Key words: Peripheral nerve, Defect, Lengthening, Nerve lengthening devices

摘要： 【摘要】〓严重的周围神经损伤,常伴有周围神经的长段缺损。如何对其进行有效的修复一直是困扰临床上外科医生的难题。传统上自体神经移植修复是最常采用的方法,但其存在很多不足,而受临床上受骨延长启发的神经缓慢延长法受到越来越多的重视,特别是对神经延长修复后的组织学、电生理学及神经延长方式等方面做了大量的研究。

关键词: 外周神经, 缺损,延长, 神经延长器

CLC Number:

R651.3

肖富文谢松林. 缓慢延长神经修复外周神经缺损的研究进展[J]. 岭南现代临床外科, 2014, 14(06): 701-703.

References

[1]Nakayama H. Recovery after peripheral nerve injury due to gradual elongation[J], J Juzen Med Soc ,1995,(104):483-491.
[2]Ikeda K, Tomita K, Tanaka S. Experimental study of peripheral nerve injury during gradual limb elongation[J]. Hand Surg, 2000,5(1):41-47.
[3] Abe I, Ochiai N, Ichimura H, et al. Internodes can nearly double in length with gradual elongation of the adult rat sciatic nerve[J]. J Orthop Res, 2004,22(3):571-577.。
[4] Kubota S, Nishiura Y, Hara Y, et al. Functional and morphological effects of indirect gradual elongation of peripheral nerve: electrophysiological and morphological changes at different elongation rates[J]. Hand Surg, 2011,16(2):105-111.
[5]Simpson AH, Halliday J, Hamilton DF, et al. Limb lengthening and peripheral nerve function-factors associated with deterioration of conduction[J]. Acta Orthop, 2013,84(6):579-584.
[6]Kodera N, Aoki T, Ito H. Electrophysiological and histological investigation on the gradual elongation of rabbit sciatic nerve[J]. J Nippon Med Sch, 2011,78(3):166-173
[7] Ichimura H, Shiga T, Abe I, et al. Distribution of sodium channels during nerve elongation in rat peripheral nerve[J]. J Orthop Sci, 2005,10(2):214-220.
[8] Yokota A, Doi M, Ohtsuka H, et al. Nerve conduction and microanatomy in the rabbit sciatic nerve after gradual limb lengthening-distraction neurogenesis[J]. J Orthop Res, 2003,21(1):36-43.
[9]Yamada Y, Nishiura Y, Saijilafu, et al. Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: cellular reaction[J]. Scand J Plast Reconstr Surg Hand Surg, 2009,43(6):297-304.
[10]Simpson AH, Gillingwater TH, Anderson H, et al. Effect of limb lengthening on internodal length and conduction velocity of peripheral nerve[J]. J Neurosci, 2013,33(10):4536-4539.
[11] Shao H, Shu H, Wang C, et al. Expression of nerve growth factor and its receptor in distracted tibial nerve after limb lengthening[J]. Anat Rec (Hoboken), 2013,296(2):333-339.
[12] Kurklu M, Demiralp B, Kirdemir V, et al. [Comparison between the distraction and grafting methods in the treatment of peripheral neural defects: an experimental study in rabbits][J]. Acta Orthop Traumatol Turc, 2005,39(2):163-171.
[13] Manders EK, Saggers GC, Diaz-Alonso P, et al. Elongation of peripheral nerve and viscera containing smooth muscle[J]. Clin Plast Surg, 1987,14(3):551-562.
[14] 劳镇国, 叶永玉, 周宏, 等. 用组织扩张器延长损伤后的周围神经远段的实验观察[J]. 中华显微外科杂志, 2000,(03):196-199.
[15] 宋知非, 陈海, 骆东山, 等. 扩张延长对周围神经影响的实验研究[J]. 中华手外科杂志, 2000,(04):54-57.
[16] Ohkaya S, Hirata H, Uchida A. Repair of nerve gap with the elongation of Wallerian degenerated nerve by tissue expansion[J]. Microsurgery, 2000,20(3):126-130.
[17] Baoguo J, Shibata M, Matsuzaki H, et al. Proximal nerve elongation vs nerve grafting in repairing segmental nerve defects in rabbits[J]. Microsurgery, 2004,24(3):213-217.
[18] Matsuzaki H, Shibata M, Jiang B, et al. Distal nerve elongation vs nerve grafting in repairing segmental nerve defects in rabbits[J]. Microsurgery, 2004,24(3):207-212.
[19] Nishiura Y, Yamada Y, Hara Y, et al. Repair of peripheral nerve defect with direct gradual lengthening of the proximal nerve stump in rats[J]. J Orthop Res, 2006,24(12):2246-2253.
[20]Zhang Z K. Animal study onrepair of long distance nerve defect effect by nerve lengthening[D].The Hong Kong Polytchnic University,2013. 115(2):10-46
[21] 金帅星, 朴虎林, 石伟, 等. 应用神经延长架延长兔坐骨神经的实验研究[J]. 中国骨伤, 2003,(02):27-30.
[22] Sharula, Hara Y, Nishiura Y, et al. Repair of the sciatic nerve defect with a direct gradual lengthening of proximal and distal nerve stumps in rabbits[J]. Plast Reconstr Surg, 2010,125(3):846-854.
[23] Nishiura Y, Hara Y, Yoshii Y, et al. Gradual stretching of the proximal nerve stump induces the growth of regenerating sprouts in rats[J]. J Orthop Res, 2008,26(7):1012-1017.