Abstract: 【Abstract】〓Objective〓To compare the effects of hypertonic saline and isotonic saline solutions on the healing of chronic traumatic wounds. Methods〓Between March 2011 and March 2014, sixty-two patients with chronic traumatic wounds were randomized to 2 groups. Thirty-one cases were treated with 28% sodium chloride medical fiber/polyester non-woven dressing (group A) and the other 31 cases, with 0.9% sodium chloride medical gauze (group B). Series of wound cultures were performed, wound conditions were assessed, and the timing of wound healing and adverse reactions were recorded. Results〓The average healing time in group A was 18.6 days. The average healing time for group B patients was 22.5 days (P<0.05). No obvious adverse effects were observed in either group. Wound cultures showed that 80% of the patients with positive pre-treatment cultures became negative after 3 days of hypertonic saline treatment whereas only 10% turned negative in group B. Conclusion〓Local hypertonic environment may significantly reduce bacteria load in chronic wounds and improve wound healing.

Key words: Local hypertonic environment, Chronic traumatic wounds, Bacterial biofilm

摘要： 〓【摘要】〓目的〓局部高渗引流及普通引流方法的比较,分析高渗环境下引流对慢性窦道的治疗效果。 方法〓慢性创伤性窦道病例62例进行随机分成2组,其中31例伤口窦道内使用28%高渗氯化钠纤维/聚酯无纺布敷料进行引流,31例使用0.9%氯化钠纱条进行引流观察治疗效果及不良反应。 结果〓28%高渗氯化钠纤维/聚酯无纺布敷料治疗组(高渗引流组)平均痊愈时间18.6天,0.9%氯化钠纱条组(等渗引流组)平均痊愈时间22.5天,两组慢性创面窦道痊愈时间差异有显著统计学意义(P<0.05);高渗引流组患者创面细菌培养阳性例数也明显低于等渗引流组。 结论〓局部高渗压环境引流可显著抑制慢性创伤性窦道细菌微生物被膜的形成,对慢性窦道的愈合有显著的效果。

关键词: 局部高渗环境, 慢性创伤性窦道, 微生物被膜