Abstract: 【Abstract】〓Objective〓To systematically evaluate the effect of dexmedetomidine on the incidence of early postoperative cognitive function in elderly patients undergoing noncardiac surgeries,so as to provide evidence for prevention and treatment of postoperative cognitive dysfunction (POCD) in elderly patients. Methods〓Databases including the Cochrane Library, PubMed, CNKI, and WanFang Data (by April 2014) were searched for randomized controlled trials (RCTs) on effect of dexmedetomidine on early postoperative cognitive function in elderly patients undergoing noncardiac surgeries. According to the modified Jadad quality scale, literature was screened, data were extracted, and quality of the included studies was critically evaluated. The meta-analysis was performed using STATE 12.0 software. Results〓A total of 19 RCTs involving 1202 patients were included. The results of meta-analyses showed that: compared with the control group, the scores on the Minimum Mental State Examination (MMSE)at the 1st and the 7th day after surgery were significantly higher in the dexmedetomidine group,and the ratio of early POCD incidence at the 1st and the seventh day after surgery in the dexmedetomidine group were significantly lower than those in the control group. Conclusion Dexmedetomidine might benefit postoperative cognitive function and might be effective for ameliorating POCD in elderly patients.

Key words: Dexmedetomidine, Cognitive function, Elderly patients, Meta-analysis

摘要：

目的 系统评价右美托咪定（dexmedetomidine，DEX）对老年患者术后认知功能的影响，为老年患者术后认知功能障碍的防治提供依据。方法 计算机检索Pubmed、Cochrane Library、CNKI和万方等数据库，手工检索图书馆馆藏期刊，检索时限截至2014年4月。按照纳入和排除标标准收集DEX对老年患者术后认知功能的影响的随机对照试验（RCT），按照改良Jadad 质量评估量表评价纳入研究的方法学质量，采用STATE 12.0软件进行Meta分析。结果 共纳入19个RCT，1202例患者。与对照组相比，DEX组术后第1天及第7天的简易精神状态检查量表评分较高，且术后第1天及第7天认知功能障碍发生率也明显减少。结论 DEX可改善老年患者术后认知功能，对减轻老年患者术后认知功能障碍有一定的防治疗效。

关键词: 右美托咪定, 认知功能, 老年患者, 系统评价, Meta分析