Abstract: 【Abstract】〓Objective〓To observe the effect of tracheal intubation on MnSSEP, investigate the feasibility of median nerve somatosensory evoked potentials for monitoring the noxious stimuli response of intubation. Methods〓Sixteen ASA Ⅰ~Ⅱ patients (8 male, 12 female) aged 18-40 yrs undergoing elective surgery under general anaesthesia. Anaesthesia was induced with TCI propofol. After the target effect-site concentration of propofol reach 5 μg·mL^{-1 and maintained for two minutes, intubation was facilitated by succinylcholine and MnSSEP, BIS, SBP, DBP, and HR of before, during and after intubation were recorded. Results〓There were no changes in all latencies of MnSSEP, BIS and HR. During intubation amplitudes of N20P25 increased, and after that they reinstated. SBP, DBP and the Amplitude of P15N20 increased during and after intubation. Conclusion〓Amplitude of N20P25 is suitable to reflect the effects of the noxious stimuli to tracheal intubation.}

Key words: Intubation, Intratracheal, Evoked potential, Somatosensory, Noxious stimuli

摘要： 【摘要】〓目的〓观察异丙酚诱导下气管插管对正中神经体感诱发电位(MnSSEP)的影响,探讨正中神经体感诱发电位用于监测气管插管引起的伤害性刺激反应的可行性。方法〓18~40岁病人20例(8男,12女), 异丙酚效应室浓度达5 ?滋g·mL-1 并用司可林后行气管插管,记录插管前、中、后的MnSSEP、BIS、SBP、DBP、HR。结果〓气管插管前后MnSSEP各波潜伏期、BIS和HR均无改变。插管即刻MnSSEP的P15N20、N20P25波幅增高,插管后N20P25恢复,P15N20仍增高,其余波幅无改变。插管即刻和插管后SBP、DBP较插管前增高。结论〓正中神经体感诱发电位的N20P25波幅较BIS更适于反映气管插管引起的伤害性刺激。

关键词: 插管法, 气管内, 诱发电位, 躯体感觉, 伤害性刺激