Abstract: 【Abstract】〓Objective〓To evaluate the neuroprotective effect of ulinastatin in paclitexel-induced peripheral neuropathy. Methods〓Twenty-four SD rats were randomized into 3 groups, the rats in group A were administered normal saline and those in group B were administered 25 kU/kg of ulinastatin. Rats in group C were administered 50 kU/kg of ulinastatin. Normal saline or ulinastatin were i.p. once per day for 7 consecutive days (from days 1 to 7). Paclitaxel (2 mg/kg per injection) was administered i.p. on four alternate days (Days 1, 3, 5 and 7; cumulative dose 8 mg/kg) after the injection of normal saline or ulinastatin. The paw withdraw threshold was measured using the von Frey test on day 0, 5, 8, 15, 21 and 28 d. Results〓The paw withdrawal thresholds were significantly increased in rats of group C compared to the other groups (P<0.01), and the paw withdrawal thresholds in rats of group B were higher than those in group A (P<0.05). Conclusion〓Ulinastatin can alleviate paclitexel-induced allodynia in a dose-dependent manner, and it could have a neuroprotective effect in paclitexel-induced peripheral neuropathy.

Key words: Paclitexel, Peripheral neuropathy, Ulinastatin

摘要： 【摘要】〓目的〓研究乌司他丁对紫杉醇引起周围神经病变的神经有保护作用。方法〓24只SD大鼠随机分为3组,A组(生理盐水+紫杉醇组)、B组(乌司他丁25 kU/kg+紫杉醇组),C组(乌司他丁50 kU/kg+紫杉醇组)。各组大鼠分别连续7天(第1至7天)注射生理盐水或乌司他丁。动物于第1,3,5,7 d完成生理盐水或者乌司他丁注射后30 min腹腔注射紫杉醇2 mg/kg,即累计总剂量为8 mg/kg。分别于0,5,8,15,21,28天使用von Frey测痛仪测定大鼠机械刺激撤足阈值。结果〓C组大鼠机械撤足阈值较A组和B组升高(P<0.01);而B组大鼠机械撤足阈值较A组升高(P<0.05)。 结论〓乌司他丁能剂量依赖性地缓解紫杉醇诱导的触诱发痛,在周围神经病变中具有神经保护作用。

关键词: 紫杉醇, 周围神经病变, 乌司他丁