Abstract: 【Abstract】 Objective To evaluate the effect of ropivacaine combined with sufentanil on inhibiting the stress reaction for the colorectal carcinoma patients undergoing radical operation. Methods Forty-six patients with colorectal carcinoma undergoing radical operation were randomly divided into the observation group (n=23) and the control group (n=23). The mixed liquor composed of 0.5 μg/mL sufentanil plus 0.15% ropivacaine was prepared for 15 mL. The patients in the observation group received injection of the mixed liquor from epidural space before skin incision,.while those in control group received the injection after recovering from an anaesthetic of surgery..The pain score (visual analogue scale,VAS).and the stress index were observed and analyzed in two groups. Results Compared with control group,.VAS in observation group was significantly lower than that in control group,.especially 3 h after surgery (P=0.026). The levels of white blood cells, neutrophils, alcohol, adrenocorticotropic hormone,..and c-reactive protein in observation group at 3 hour time point were significantly lower than that in control group(P<0.05). Conclusion Ropivacaine combined with sufentanil could effectively inhibit the stress reaction for the colorectal carcinoma patients undergoing radical operation.

Key words: Ropivacaine, Preventive analgesia, Stress reaction, Colon cancer

摘要： 【摘要】 目的 评价罗哌卡因联合舒芬太尼在抑制结肠癌根治术患者应激的效果。方法 46例结肠癌根治术患者随机分为观察组及对照组各23例,配制0.5 ug/mL舒芬太尼+0.15%罗哌卡因混合液15 mL,观察组患者于切皮前从硬膜外腔注入上述混合液;对照组患者在术毕清醒后从硬膜外腔注入上述混合液,观察两组的疼痛与应激指标差异。结果 与对照组比较,观察组的疼痛视觉评分(VAS)评分更低,尤其在术后3 h时相(P=0.026)。术后3 h观察组的白细胞、中性粒细胞、皮醇、促肾上腺皮质激素及C反应蛋白的含量均显著低于对照组(P<0.05),且以皮质醇的差异最为明显。结论 给予罗哌卡因联合舒芬太尼超前镇痛可有效抑制结肠癌根治术患者的应激反应。

关键词: 罗哌卡因, 超前镇痛, 应激反应, 结肠癌