Abstract:

【Abstract】 Objective To investigate the clinical efficacy of intermittent use of finasteride for benign prostatic hyperplasia (BPH). Methods A total of 105 patients with BPH were divided into three groups according to administering the dose of finasteride,.Group A (finasteride 5 mg 1/d), group B (5 mg/2 days) and group C.(5 mg/3 days)..After 3 years of treatment,.IPSS score,.maximum flow rate,.prostate volume,B-mode ultrasound measured residual urine volume and IIEF-5 were measured and analyzed. Results Group C was canceled ahead of schedule for high incidence of exacerbation. After treatment,.there were no statistically significant differences between group A and group B in terms of IPSS score, prostate volume, B-mode ultrasound measured residual urine volume and IIEF-5(P>0.05). Compared with group A, the maxium flow rate significantly decreased in group B after 3 years treatment (P<0.05). Conclusion The usage of 5 mg/2 days of finasteride may be as effective as daily administration for the treatment of BPH.

Key words: Finasteride, Benign prostatic hyperplasia, Clinical efficacy

摘要：

【摘要】 目的 探讨低剂量非那雄胺维持治疗良性前列腺增生症的中远期疗效。方法 将105例经非那雄胺治疗显效的良性前列腺增生症病例随机分为3组,分别予以非那雄胺5 mg 1次/d、5 mg 1次/2 d及5 mg 1次/3d维持治疗3年,比较其各时点IPSS、Qmax、V、Ru和IIEF等指标的差异。结果 非那雄胺5 mg 1次/3 d维持治疗组不能完成实验,非那雄胺5mg 1次/2 d维持治疗组除3年时点Qmax较低外,其余各时点指标与5 mg 1次/d维持治疗组比较无显著差异。结论 非那雄胺5mg 1次/2 d维持治疗给药基本能维持良性前列腺增生症的中远期临床疗效。

关键词: 低剂量, 非那雄胺, 性前列腺增生症, 疗效