Research on the role of heat shock proteins in carcinogenesis,.proliferation,.recurrence, metastasis and anti-tumor immune responses of hepatocellular carcinoma

doi:10.3969/j.issn.1009-976X.2013.04.033

Abstract

Abstract:

【Abstract】 Heat shock proteins (HSPs) are a class of proteins with extremely conservation, which involve in many vital chaperoning processes such as protein folding, transporting, stabilization and antigenic presentation. Some of the HSPs, such as HSP27, HSP70, and HSP90, are frequently overexpressed in hepatocellular carcinoma(HCC). This review summarizes the role of HSPs in carcinogenesis, proliferation, recurrence, metastasis and anti-tumor immune responses of HCC.

Key words: Carcinoma, hepatocellular, Heat shock proteins

摘要：

【摘要】热休克蛋白(heat shock proteins, HSPs)是一类结构高度保守的蛋白质,主要参与蛋白的转运、折叠、维持蛋白质自身稳定及免疫应答。大量研究表明,HSPs中多个成员如HSP27、HSP70及HSP90,在肝细胞癌(hepatocellular carcinoma, HCC)中呈过表达。本文就HSPs在肝细胞癌的形成、增殖、复发、转移及抗肿瘤免疫的作用进行综述。

关键词: 热休克蛋白类, 癌, 肝细胞

CLC Number:

R602

Wu Jiayi,Li Gaopeng, Luo Baoming. Research on the role of heat shock proteins in carcinogenesis,.proliferation,.recurrence, metastasis and anti-tumor immune responses of hepatocellular carcinoma[J]. Lingnan Modern Clinics in Surgery, 2013, 13(04): 367-369.

吴嘉仪李高鹏罗葆明. 热休克蛋白在肝细胞癌形成、增殖、复发、转移及抗肿瘤免疫中的作用研究[J]. 岭南现代临床外科, 2013, 13(04): 367-369.

References

[1] 汤钊猷. 开展肝癌转移复发研究的意义与途径[J]. 中华普通外科杂志.2006，21(4)：761.
[2] Lim SO, Park SG, Yoo JH, et al. Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules[J]. World J Gastroenterol,2005,11(14):2072-2079.
[3] 戴凤姣，冯茂辉，谢伟，等. HSP27在肝癌中的表达及临床意义[J]. 中国肿瘤临床.2009，36(10)：578-581.
[4] Yasuda E, Kumada T, Takai S, et al. Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma[J]. Biochem Biophys Res Commun,2005,337(1):337-342.
[5] 孙雪峰，何松. 肝癌细胞中热休克蛋白27相互作用蛋白的分离和鉴定[J]. 重庆医科大学学报.2010，35(8)：1221-1223.
[6] Guo K, Kang NX, Li Y, et al. Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis[J]. BMC Cancer,2009,9:100.
[7] Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma[J]. Hepatology,2003,37(1):198-207.
[8] 李华民，张晓丽，胡沛臻，等. 肝癌及癌旁肝组织中P53蛋白及热休克蛋白70的表达及意义[J]. 陕西医学杂志.2002，31(8)：681-683.
[9] 李航宇，孔凡民，董明，等. HSP70和JNK信号转导通路在肝癌组织中的表达及意义[J]. 中国组织化学与细胞化学杂志.2006，15(3)：240-245.
[10] 李三峰，丁伟. HSP70与p53蛋白在肝细胞癌组织中的表达及相关性研究[J]. 肿瘤基础与临床.2009，22(6)：468-471.
[11] 崔崇伟，杨守京，刘雁平，等. 人肝癌组织中p53与HSP70相互作用的初步研究[J]. 细胞与分子免疫学杂志.2003，19(2)：195-196, 199.
[12] Zhu XD, Li CL, Lang ZW, et al. Significant correlation between expression level of HSP gp96 and progression of hepatitis B virus induced diseases[J]. World J Gastroenterol,2004,10(8)：1141-1145.
[13] 吴胜利，潘承恩，牛新捷，等. 原发性肝癌中HSP90α的表达及意义[J]. 中华肝胆外科杂志.2003，9(2)：88-90.
[14] 张杰，刘军建，张宁，等. 人肝细胞癌及其配对非癌肝组织、正常肝组织中热休克蛋白Hsp90基因mRNA水平分析[J]. 中国生物化学与分子生物学报.2001，17(3)：386-390.
[15] Zhang H, Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90[J]. J Mol Med (Berl),2004,82(8):488-499.
[16] Pascale RM, Simile MM, Calvisi DF, et al. Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer[J]. Hepatology,2005,42(6):1310-1319.
[17] 郭坤，刘银坤，周海君，等. 热休克蛋白27在转移潜能不同人肝癌细胞系中的表达及机制研究[J]. 生物化学与生物物理进展.2007，34(7)：738-745.
[18] 梁鼎奇，吕小平，詹灵凌，等. 肝细胞癌组织中Cyr61、VEGF和HSP27的表达及意义[J]. 山东医药.2011，51(9)：19-21.
[19] Song HY, Liu YK, Feng JT, et al. Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues[J]. J Cancer Res Clin Oncol,2006,132(2):92-98.
[20] Guo K, Liu Y, Zhou H, et al. Involvement of protein kinase C beta-extracellular signal-regulating kinase 1/2/p38 mitogen-activated protein kinase-heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion[J]. Cancer Sci,2008,99(3):486-496.
[21] Yang F, Yin Y, Wang F, et al. miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway[J]. Hepatology,2010,51(5):1614-1623.
[22] Takai S, Matsushima-Nishiwaki R, Tokuda H, et al. Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma[J]. Life Sci,2007,81(7):585-591.
[23] Joo M, Chi J G, Lee H. Expressions of HSP70 and HSP27 in hepatocellular carcinoma[J]. J Korean Med Sci,2005,20(5):829-834.
[24] Luk JM, Lam CT, Siu AF, et al. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values[J]. Proteomics,2006,6(3):1049-1057.
[25] 郭晓东，杨永平，孙婷，等. HIF-1 α、HSP90α在肝细胞癌中的表达及临床意义[J]. 现代生物医学进展.2010，10(24):4679-4682.
[26] Srivastava PK. Immunotherapy for human cancer using heat shock protein-peptide complexes[J]. Current Oncology Reports,2005,7(2):104-108.
[27] 胡廷辉，应敏刚. 热休克蛋白70多肽复合物与肿瘤免疫[J]. 福建医科大学学报.2006，40(3)：308.
[28] 吴信华，庄红芹，鞠少卿，等. 热休克蛋白gp96-肽复合物体外对人肝癌细胞的抗肿瘤效应[J]. 江苏医药.2011，37(4)：409-411.
[29] 傅庆国，孟凡东，郭克建，等. 热休克蛋白70在诱导肿瘤免疫中的效应[J]. 中华微生物学和免疫学杂志.2003，23(1)：31-33.
[30] Schueller G, Kettenbach J, Sedivy R, et al. Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo[J]. Int J Oncol,2004,24(3):609-613.
[31] Basu S, Binder R J, Suto R, et al. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway[J]. Int Immunol,2000,12(11):1539-1546.
[32] Haen SP, Gouttefangeas C, Schmidt D, et al. Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation[J]. Cell Stress Chaperones,2011,16(5):495-504.
[33] Widenmeyer M, Shebzukhov Y, Haen SP, et al. Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation[J]. Int J Cancer,2011,128(11):2653-2662.