关键词: 丙泊酚, Marsh, 宫腔镜, Schnider, 靶控输注

Abstract: Objective To evaluate the applicability of target controlled infusion（TCI）with propofol by Marsh model and Schnider model during hysteroscopic surgery. Methods Sixty unpremedicated gynecologic patients，aged 20-60 yr，with body mass index of 18-30，American Society of Anesthesiologists physical status I or II undergoing hysteroscopic surgery in SunYat?sen Memorial Hospital from January of 2017 to June of 2018 were divided into M and S groups（n=30 each）. Propofol was administered by TCI， with respectively March model and Schnider model in two groups，and the depth of anesthesia was monitored by Narcotrend. The applicability of two models was evaluated by ASA status ，age，BMI，operative time， propofol dosage per unit time ，number of body movement ，TCI parameter adjustment ，hypotension， sinus bradycardia，assistant breathing during the operation. The Narcotrend index date in the time of basic state（T0），loss of consciousness（T1），expansion of cervical（T2），end of anesthesia（T3）were collected and analyzed.Also recovery time of consciousness，number of nausea and vomiting，chill were recorded. Results There was no significant difference in the ASA status，age，BMI，operative time between group M and group S（P > 0.05）. The propofol dosage per unit time in group M were less than group S（P <0.001），number of body movement in group M was more than group S（P < 0.05），TCI parameter adjustment in group M was more than group S too（P < 0.01），but hypotension，sinus bradycardia，assistant breathing during the operation have no significant difference between the two groups. There was no significant difference in NTI between group M and group S in T0（P>0.05），NTI were higher in group M than group S in T1 and T2（P<0.01），but no significant difference in T3 between the two groups（P>0.05）. There was no significant difference in the recovery time of consciousness，number of nausea and vomiting，chill between group M and group S（P>0.05）. Conclusion Schnider model was better than Marsh model in propofol TCI during hysteroscopic surgery.

Key words: target controlled infusion, schnider, hysteroscopic surgery, marsh, propofol