关键词: 肿瘤细胞减灭术, 目标导向液体治疗, 腹腔热灌注化疗

Abstract: Objective To investigate the effect of goal?directed fluid therapy（GDFT）in cytoreductive surgery（CRS）combined hyperthermic intraperitoneal chemotherapy（HIPEC）. Methods This was a prospective approach. Eighty?six peritoneal metastases patients receiving CRS combined HIPEC were assigned to the control group and GDFT group （43 cases each group）. In the perioperative period ， patients in the control group received classical fluid therapy and patients in GDFT group received GDFT. Patients′ general information，hemodynamic index during surgery，lactic acid at the end of surgery， length of hospitalization，urine volume，intraoperative volume replacement，intraoperative bleeding volume ， usage of furosemide and dopamine，postoperative complications，intensive care unit（ICU）readmission and perioperative mortality were recorded. Results There were no significant differences in patients′ general information between two groups （P>0.05）. Crystalloid volume replacement and total volume replacement were significantly lower and colloid volume replacement was significantly higher in the experimental group than that in the control group （P<0.05）. Mean arterial pressure 30 min after surgery was significantly lower in the experimental group than that in the control group（P<0.05）. The ratio of usage of furosemide and dopamine，lactic acid at the end of surgery，length of hospitalization，ratio of postoperative abdominal，cardiac，respiratory and hepatic complication and ICU readmission were significantly lower in the experimental group than that in the control group （P<0.05）. Conclusion GDFT could decrease intraoperative volume replacement，postoperative complications and length of hospitalization.

Key words: goal?directed fluid therapy, cytoreductive surgery, hyperthermic intraperitoneal chemotherapy