关键词: 开腹手术, 胃肠间质瘤, 肿瘤直径, 腹腔镜手术, 可行性

Abstract: Objective To explore the efficacy and feasibility of laparoscopic minimally invasive surgery in the treatment of 5~8 cm gastrointestinal stromal tumor（GIST）. Methods The clinical data of each 48 patients with GIST of 5~8 cm diameter who underwent laparoscopic surgery（observation group） and laparotomy（control group）were retrospectively analyzed. The operation indexes（including operative time ，intraoperative blood loss ，incision length） and postoperative recovery （including postoperative exhaust time，postoperative feeding time，postoperative hospital stay）were compared between the two groups. And the complications within three months after operation ，recurrence，metastasis and death at one year after operation，and physical status ［Eastern Cooperative Oncology Group Score （ECOG）］ were also compared between the two groups. Results The operative time ，intraoperative blood loss ， incision length ， postoperative exhaust time ， postoperative feeding time and postoperative hospital stay in observation group were significantly lower than those in control group （P<0.05）. There was no significant difference in the occurrence of complications between the two groups within three months after operation （P>0.05）. At one year after operation ，there were no significant differences in recurrence ， metastasis ，and death status and physical status （ECOG score） between the two groups （P>0.05）. Conclusion Laparoscopic surgery and laparotomy have significant short?term efficacy and safety in the treatment of GIST with a diameter of 5~8 cm，and laparoscopic surgery has a good minimally invasive advantage and is more beneficial in promoting postoperative recovery.

Key words: feasibility, laparoscopic surgery, gastrointestinal stromal tumor, tumor diameter, laparotomy