关键词: 血糖, 地氟醚, 七氟醚, 乳酸

Abstract: ［Abstract］ Objective To investigate the effects of desflurane and sevoflurane on blood glucose and lactic acid in patients with brain tumor. Methods Sixty four patients with brain tumor, aged 21-62 yr, American Society of Anesthesiologists status Ⅰ-Ⅱ, with body mass index of 20-25, scheduled for brain tumor resection surgery, were assigned into desflurane group（Group Des, n=30）and sevoflurane group （Group Sevo, n=34）using a random number table, the two groups were anesthetized with desflurane and sevoflurane respectively. 1 mL artery blood sample were taken to detect the levels of blood glucose and lactic acid at each time of before operation（T0）, one hour after operation（T1）, two hours after operation（T2）, end of operation（T3）. Results The level of blood glucose in both group were significant increased（P<0.01）, but there were no statistical difference between the two groups（P>0.05）. There were no significant increase on the level of lactic acid in both group（P>0.05）, also, no statistical difference between the two groups （P>0.05）. Conclusion Both desflurane and sevoflurane anesthesia increase blood glucose levels in patients with brain tumors.

Key words: sevoflurane, desflurane, blood glucose, lactic acid