关键词: 腰丛阻滞, 盐酸甲哌卡因, 浓度, 安全性, 有效性

Abstract: ［Abstract］ Objective To observe the clinical efficacy and safety of the three different concentrations of mepivacaine hydrochloride during lumbar plexus block for patients undergoing single lower limb surgery. Methods Seventy-five adult patients with ASA Ⅰ- Ⅱ ，undergoing single lower limb surgery，were randomly divided into 3 groups including 0.25% ， 0.5% and 0.75% （n=25）， according to the concentration of mepivacaine. All patients were performed lumbar plexus block guided by ultrasound and nerve stimulator. 35 ml of 0.25% mepivacaine was injected in group 0.25% ，35ml of 0.5% mepivacaine in group 0.5% ，and 35 ml of 0.75% mepivacaine in group 0.75%. The onset time，duration，blocking extent and the occurrence of adverse events were recorded after lumbar plexus block. Results The onset time of sensory block in the three groups was 23.7±3.8 min，15.5±3.4 min，10.2±3.1 min，respectively， with significant difference between any two groups（P<0.01）. The duration of sensory and motor block in group 0.75% were longer than that of group 0.5%（P<0.01）. The onset time of motor block in group 0.75% was shorter than that of group 0.5%（P<0.01）. The blocking extent of group 0.5% or group 0.75% was greater than that of group 0.25%（P<0.05），with no significant difference between group 0.5% and group 0.75% . All patients in group 0.5% or group 0.75% completed the surgery only under nerve complete the surgery for poor outcome of nerve blockade. No complications such as local anesthetic poisoning， epidural block， postoperative neurological dysfunction were observed. Conclusion Mepivacaine hydrochloride can be used safely and effectively in lumbar plexus block for adult patients undergoing single lower limb surgery. And the concentration of 0.5%- 0.75% can achieve satisfactory blocking outcomes.

Key words: mepivacaine hydrochloride, concentration, lumbar plexus block, efficacy, safety