关键词: 全膝关节置换术, 氨甲环酸, 术后出血, 下肢深静脉血栓, 局部注射

Abstract: ［Abstract］ Objective To summarize the clinical data from local injection of tranexamic acid on unilateral total knee arthroplasty forthe first time in patients with postoperative blood loss. Methods Eighty cases of patients who underwent the unilateral total knee arthroplasty in our hospital were selected as the research objects，and all patients were admitted to the hospital for osteoarthritis，and all were performed the operation for the first time. The patients were divided into the observation group and the control group according to the principle of randomized control. The observation group were injected the 10 ml tranexamic acid in the capsule of the joint before closing the joint cavity ，while the control group were injected with 10 ml normal saline. Then，two groups were placed the high negative pressure drainage bottle after the injection，and the hemoglobin，flow rate，blood transfusion，and complications of deep venous thrombosis of the lower extremities after operation of two groups were compared. Results The flow rate and the condition of blood loss after operation for 24 h in the observation group was significantly lower than that in the control group （P<0.05）. The erythrocyte specific volume and hemoglobin index after operation in the observation group were higher than those in the control group ， and the difference between the two groups was statistically significant（P<0.05）. The blood transfusion rate and blood transfusion rate in the observation group were lower than that in the control group （P< 0.05）. There was no statistical difference in the probability of deep venous thrombosis after the operation between the two groups（P>0.05）. Conclusion The tranexamic acid injection on the basis of negative pressure drainage treatment for patients with total knee arthroplasty which can effectively reduce postoperative bleeding and reduce the demand for blood transfusion. At the same time，it does not promote the risk of deep venous thrombosis of the lower extremity，thus it is worth further promoting and applying in clinical practice.

Key words: tranexamic acid, local injection, lower extremity deep venous thrombosis, total knee arthroplasty, postoperative bleeding