关键词: Polo样激酶3, 转移, 前列腺癌, 增殖

Abstract: Objective To investigate the expression of Polo?like kinase 3（Plk3）in prostate cancerand its clinical significance. Methods Immunohistochemistry was performed to detect the expression of Plk3 in the tissues of 68 cases of prostate cancer and 10 cases of prostate. The relationship between the expression of Plk3 and clinicopathological features was analyzed. GSEA analysis was conducted to explore relationship between gene sets of proliferation or metastasis and Plk3 expression in 498 cases of prostate cancer in TCGA database. Results The positive rate of Plk3 in prostate cancer tissues was significantly higher than that in normal prostate tissues（P=0.034）. The expression of Plk3 was correlated with the pathological grade, clinical stage, tumor stage, lymph node metastasis and distant metastasis（P<0.05）but not age and Gleason score（P>0.05）. The results of GSEA analysis showed that Plk3 was associated with the proliferation and metastasis of prostate cancer. Conclusion Plk3 is up?regulated in prostate cancer and promotes the progression of prostate cancer, which may play a role in promoting proliferation and metastasis.

Key words: Polo?like kinase 3, proliferation, metastasis, prostate cancer