关键词: SOFA评分, 脓毒症, 血栓弹力图, 病情评估

Abstract: ［Abstract］ Objective To study the value of thromboelastography（TEG）in the evaluation of sepsis. Methods Fifty?five patients with sepsis from April 2017 to November 2017 in the Department of Critical Care Medicine of Sun Yat?sen Memorial Hospital, Sun Yat?sen University were analyzed retrospectively. According to the SOFA score, the patients were divided into Group A（SOFA score≥ 10）（26 cases）and Group B （10>SOFA score≥2）（31 cases）. Another 43 cases with non?sepsis and normal coagulation function were selected as a control group（Group C）. The venous blood was collected for TEG, and then analysis and comparison of various TEG indicators between groups. Results The time of coagulation reaction（R value）and thrombin formation（K value）were compared in each group：Group A > Group C > Group B, the results were statistically significant （P<0.05）, the rate of fibrin clot formation and reinforcement（α Angle）and the maximum strength and hardness of blood clot（MA value）：Group A < Group C < Group B, the results were statistically significant （P<0.05）. R and K value were positively correlated with the SOFA score （All P values <0.05）, and α Angle, MA value were significantly negatively correlated with the SOFA score（All P values <0.05）. The 28?day mortality rate of Group B was 12.9% and with the increase of SOFA score, the 28?day mortality rate of Group A was 46.1%. Conclusion Thromboelastography can analyze the coagulation status of sepsis patients comprehensively and accurately, and there is a significant correlation with SOFA score. Monitoring the thromboelastography is of great significance to evaluate the severity of sepsis patients and guide the treatment.

Key words: sepsis, thromboelastography, evaluation, SOFA score