关键词: 机械通气, 肺损伤, 右美托咪定, ARDS, 炎症因子

Abstract: ［Abstract］ Objective To analyze the effects of dexmedetomidine on inflammation factors and lung injury in ARDS patients during ventilation. Methods This article consisted of forty patients with acute respiratory distress syndrome（ARDS）who had been hospitalized in our hospital from. The patients were divided into two groups according to using dexmedetomidin（dexmedetomidine group, n=20）or without using dexmedetomidine （control group, n=20）. The patients of dexmedetomidine group received the management of intravenously infused with dexmedetomidine 1 μg/kg to 15 min, and followed by 0.2?0.7 μg（/kg·h）. Propofol was given intravenously the ratio of 3?5 mg（/kg·h） until 48 h later in control group. All patients were administrated with sufentanil 0.1?0.2 μg（/kg·h）in both groups. Blood was draw from vein to detect IL?6, IL?8, IL?10, and PaO2/FiO2 was recorded respectively at pre?intubation（T0）, 6 h（T1）, 12 h（T2）, 24 h（T3）and 48 h after intubation（T4）. Results Compared with T0 , the levels of IL?6, IL?8 and IL?10 were higher at T1 ?T4 in two groups（P<0.05）. PaO2/FiO2 was higher at T2 ?T4 in dexmedetomidine group and were lower at T1 ?T4 than in control group（P<0.05）. HR were higher at T1 ?T4 in dexmedetomidine group and lower in control group （P<0.05）. Compared with control group, the patients in dexmedetomidine group showed lower levels of IL?6, IL?8 and higher levels of IL?10 and PaO2/ FiO2 at T2?T4 （P<0.05）. Conclusion Administration of dexmedetomidine for the ARDS patients with mechanical ventilation reduces the release of inflammatory factors and may reduce lung injury.

Key words: inflammation factors, ARDS, lung injury, dexmedetomidine, ventilation