关键词: 乳腺癌, 钼靶, KI-67

Abstract: Objective To investigate the relationship between Ki-67 and clinical，pathological and molybdenum target BI- RADS grading of breast cancer. Methods Clinical data of 199 female patients with breast cancer treated in Xiaogan Central Hospital from January 2015 to December 2016 were retrospectively analyzed，including clinical，pathological and molybdenum target BI-RADS classification. Results Ki- 67 labeling index was correlated with tumor diameter ，lymph node metastasis status，molybdenum target BI- RADS grading，ER，PR，HER- 2 and WHO grading of invasive ductal carcinoma （all P values <0.05），uncorrelated with age （P>0.05）. The average Ki- 67 labeling index value of medullary carcinoma（61.47%）was greater than that of the invasive ductal carcinoma（36.26%）， mucinous carcinoma（15.10%），invasive lobular carcinoma（20.62%）and ductal carcinoma（12.53%）（all P values <0.05）；The average Ki-67 index value of invasive ductal carcinoma was higher than that of mucinous carcinoma and ductal carcinoma（all P values <0.05）. The average Ki-67 index value of luminal A subtype（7.23%）was significantly lower than that of luminal B（35.43%），HER- 2 overexpression （39.58%）and triple negative（57.26%）subtypes（P<0.05 for all）. The average value of Ki-67 index in luminal B subtype was less than that in HER-2 overexpression subtype（P<0.05）. The mean value of Ki-67 index of triple-negative subtype were higher than those of non-triple-negative subtype（30.20%）（P<0.05）. Conclusion Ki- 67 level was related to the clinical，pathological and molybdenum target BI-RADS grading of breast cancer patients，and it has some guidling significance for the treatment and prognosis of breast cancer.

Key words: molybdenum target, breast cancer, Ki-67