关键词: 氨甲环酸, 关节腔, 膝关节置换, 失血量, 静脉血栓栓塞

Abstract:

Objective To explore the blood loss and the safety of intra-articular injection of tranexamic acid during unilateral total knee arthroplasty. Methods Sixty patients were enrolled from June 2014 to June 2016, and assigned to two groups, observation group and control group. All patients underwent unilateral total knee arthroplasty （TKA）. In the observation group, had an intra-articular injection of 1 g（20 ml）tranexamic acid and drain clamping for 4 h postoperatively. And in the control group, 20 ml saline was given by intra-articular injection after the surgery and the drain was clamped for 4 hours. Blood loss, drain volume, hidden blood loss and the incidence of deep venous thrombosis between the two groups were recorded. Results Total blood loss, total drainage, cult blood loss were lower in the observation group than that in control group（all P values<0.05）. There were no deep venous thrombosis or other complications in either group. Conclusion Immediately postoperative intra-articular retrograde injection of TA and 4 h of drain-clamping effectively reduced blood loss after TKA.

Key words: total knee arthroplasty, blood loss, intra-articular, venous thromboembolism, tranexamic acid