关键词: 分化型甲状腺癌, 骨密度 , 左旋甲状腺素, 女性患者, TSH抑制

Abstract:

Objective To investigate the influence of suppressive levothyroxine therapy on bone mineral density（BMD） in women with differentiated thyroid carcinoma after thyroidectomy. Methods A total of 46 female patients with differentiated thyroid carcinoma who underwent total or near total thyroidectomy in Jiangmen Central Hospital from 2010 to 2014, were enrolled in this study. Pre-and post-operative BMD（T-score）of lumbar（L1-L4）and femur were detected and compared in each groups include age, BMI, menopausal status, initial target TSH level and average TSH level. Results Repeated measurement ANOVA showed that T-score of lumbar（L1-L4） and femur after suppressive levothyroxine therapy had significantly differences（P<0.05） in each group included group age, menopausal status and initial target TSH level. There was interaction between time effect and group effect in group initial target TSH level and group average TSH level. Conclusion Elder postmenopausal female patients with DTC who underwent long-term suppressive levothyroxine therapy, should be accepted primary prevention against osteoporosis no matter what TSH level they maintain. And also female patients who have lower initial target TSH level（≤0.01 mIU/L）, should keep on primary prevention against osteoporosis.

Key words: levothyroxine, bone mineral density, TSH suppressive, female patients, differentiated thyroid carcinoma