关键词: 全麻患者拔管 , 右美托嘧啶, 胸腔镜手术

Abstract:

Objective To investigate the effect of dexmedetomidine（DEX）during general anes-thesia extubation on the patients receiving thoracoscopy operation. Methods Sixty patients scheduled for thoracoscopic lobectomy were divied into dexmedetomidine group and control group, 30 patients in each group. At 30 minutes before the end of procedure, the patients in dexmedetomidine group and con-trol group were given dexmedetomidine and 0.9% sodium chloride solution injection based on 0.5 g/kg · min, respectively. The recording physiological indicators included heart rate, blood pressure and blood oxygen saturation of the patient at the time of before operation, finishing operation, during extubation, 1 minute after extubation, 5 minute after extubation. And recording operation time, awake time, exbura-tion time, orientation recovery time and incidence of adverse reactions were also recorded. Results The heart rate and blood pressure of dexmedetomidine group were lower than that of control group at the time of during extubation, 1 minute after extubation, 5 minute after extubation （all P values<0.05）. More transient bardycardia and lower shiver occurred in dexmedetomidine group when compared to control group（P<0.05）. At time of extubation, there was no any significant difference in blood oxygen satura-tion, operation time, awake time, exburation time, orientation recovery time. Conclusions Dexmedeto-midine can constrain the adverse reactions and stable hemodynamic state with adequate pain relief, while no significant delaying of wawken and extubation time in patients undergoing thoracoscopic lobectomy.

Key words: thoracoscopic procedure, general anesthesia during exburation, dexmedetomidine