关键词: 热痛, 机械痛 , 感觉功能

Abstract:

 Objective To compare the two sensory function evaluation Methods as the hot plate pain test and up-down mechanical pain test about their stability and accuracy. Methods Ten Male C57BL/6J mice weighed 20 to 25 g were included, and the thermo-hot plate pain detector was used to measure the response latency in hot pain, the Von Frey Hair Test fiber was used to measure the 50% mechanical drop threshold. The stability and accuracy of the two sensory function assessment Methods were compared. Results The three times of response latency to heat pain were 26.24 ± 7.36 s, 22.28 ± 7.78 s, 20.80±6.85 s and there was no significant difference between these three groups（P>0.05）. The three times mechanical withdrawal thresholds of left foot were ：2.69±1.22 g, 2.71±1.19 g, 2.58±1.15 g and there was no significant difference between these three groups（P>0.05）. The three times mechanical withdrawal thresholds of right foot were 2.97±1.07 g, 2.99±1.03 g, 2.99±1.04 g and there was no signifi-cant difference between these three groups（P>0.05）. Conclusion There was no significant difference between the three times hot pains measure, and no significant difference in both three times of the left and right foot mechanical pain.

Key words: sensory function, hot pain, mechanical pain