关键词: 老年, 辅助化疗 , 乳腺癌

Abstract:

  Objective To explore the effect of postoperative adjuvant chemotherapy on progno? sis of elderly breast cancer. Methods The data of 80 patients with breast cancer who were hospitalized for Ⅰ~ⅢA ≥65 years of age from Jan. 2003 to Dec. 2013 were analyzed. Of 80 cases，47 cases received adjuvant chemotherapy ， 33 cases did not received adjuvant chemotherapy. The clinicopathological features and clinical treatment characteristics were analyzed. Results Compared with patients who not received postoperative adjuvant chemotherapy ，patients received adjuvant chemotherapy were younger （P=0.005），with fewer comorbidities （P=0.040），higher rates of axillary lymph node metastasis （P< 0.001），more the rate of ER/PR negative（P=0.029），more the rate of receiving radiotherapy（P=0.005）. There were no significant differences in tumor histological grade ，tumor size，HER2 expression，operation and endocrine therapy（P>0.05）. The median follow?up 73 months，between adjuvant chemotherapy group and non?adjuvant chemotherapy group ，in which disease?free survival（ DFS ）had no signifi? cant difference （78.7% vs 90.9% ，P=0.147），overall survival（OS）also was not significantly different（83.0% vs 93.9%，P=0.098）. Conclusions The benefit for elderly patients with postoperative adjuvant chemotherapy for breast cancer is not obvious. But for those in younger ，less complications asso? ciated with axillary lymph node metastasis ，ER/PR negative，the patients should be comprehensively as? sessed for the tolerance and benefit before postoperative adjuvant chemotherapy.

Key words: aged, adjuvant chemotherapy, breast cancer