关键词: 进展期结直肠癌, 腹腔热灌注化疗, 联合化疗, 全身化疗

Abstract: 【Abstract】 Objective To investigate the clinical efficacy and adverse reaction by implement of abdominal hot perfusion chemotherapy on advanced colorectal cancer after laparoscopic radical resection. Methods Seven- eight cases of advanced colorectal cancer patients were recruited and assigned to two groups，39 cases in each group. The patients in combined chemotherapy group underwent laparoscopic radical colorectal cancer resection combined with intraperitoneal hyperthermic chemotherapy（IPHC）for 3 times after surgery，then received the conventional systemic chemotherapy（XELOX），and those in single chemotherapy group were performed systemic chemotherapy alone in 4 weeks after laparoscopic radical colorectal cancer resection. The clinical efficacy and safety were evaluated in patients of two groups. KPS score，adverse reaction，survival rate were recorded and analyzed. Results The KPS score increased at a rate of 53.85% in combined chemotherapy group，and 25.64% in single chemotherapy group. The difference between two groups had statistical significance（P<0.05）. There was no difference between two groups in incidence of the adverse reaction. The 1-year，3-year and 5-year survival rates were respectively 92.31%，64.10% and 46.15%. The 3-year and 5-year survival rates were rising when compared with single chemotherapy group（all P values less than 0.05）. Conclusion For advanced colorectal cancer patients, IPHC supplementation based on systemic chemotherapy generally provides improvement in survival after laparoscopic radical resection，and had less adverse reactions during chemotherapy.

Key words: intraperitoneal hyperthermic chemotherapy, combined chemotherapy, advanced colorectal cancer, systemic chemotherapy