关键词: RNA结合蛋白24, 乳腺组织, 预后

Abstract: 【Abstract】 Objective To explore the expression of RNA?binding protein 24 and its prognostic significance in breast cancer. Methods Twenty?four pairs of breast cancer tissues and paraneoplastic breast tissues were collected. The mRNA and protein of RBM24 in these tissue samples were detected by reverse transcription?polymerase chain reaction （RT?PCR）and western blotting. Meanwhile，we examined the clinical significance of RBM24 in breast carcinoma using TCGA data. Results The mRNA and protein of RBM24 was significantly higher in the paraneoplastic breast tissues than in the breast cancer tissues（P<0.001）. Kaplan?Meier univariate survival analysis suggested that high RBM24 expression was associated with poor overall survival（P<0.05）. Conclusion RBM24 was downregulated in breast cancer，which was associated with poor prognosis. Therefore, RBM24 may serve as a prognostic biomarker for breast cancer.

Key words: RNA?binding protein 24, prognosis, breast cancer