关键词: 帕瑞昔布, 腹股沟疝无张力修补术, 切口局麻

Abstract: 【Abstract】 Objective To investigate the postoperative analgesic effect of parecoxib following free -tension inguinal hemioplasty when local anesthetics was infiltrated at incision site. Methods Two hundred patients undergoing free-tension inguinal hemioplasty under spinal anesthesia were assigned to four groups, each group of 50 cases. The patients in the group A received intravenous 4 ml saline and incision infiltration with saline in ten minutes before the end of operation. The patients in group B received intravenous parecoxib 40 mg and incision infiltration with saline. Those in group C received intravenous 4 ml saline and incision infiltration with 0.75% ropivacaine. And those in group D received intravenous parecoxib 40 mg and incision infiltration with 0.75% ropivacaine. The observation time points included T1（6 hours after operation）, T2（24 hours after operation）. VAS values, additional requirement of opioids analgesia 24 hours after the operation, the rate of satisfactory with analgesia quality were compared between four groups. Results There was no significant difference between group A and group B of the VAS scores at time point T1, while the VAS values of group D was significantly lower than other three groups（all P values < 0.05）. Group C was also significantly lower than group A and group B（all P values <0.05）. There was no significant difference among the three groups（group A, B and C）of the VAS values at time point T2（P>0.05）, while the VAS values of group D was significantly lower than others（P<0.05）. Three patients（6%）received additional analgesics in the group D and significantly lower than other three groups（all P values <0.05），while there was no significant difference among the other three groups. The rate of satisfactory with analgesia in group D（86%）was significantly higher than other three groups（P<0.05），while there was no significant difference among the other three groups. Conclusion Paricoxib combined with local anesthetics infiltration can significantly relieve the pain of early stage after operation in the patients receiving free-tension inguinal hemioplasty.

Key words: Local anesthetics, Free-tension inguinal hemioplasty, Parecoxib