关键词: TGF-β1, 输尿管狭窄, PIP

Abstract:

【Abstract】 Objective To determine the effect of PIP controlled-release stents which specific silencing of TGF-β1 in prevention of ureteral stricture. Methods A rabbit model of ureteral stricture was constructed in 20 New Zealand rabbits and was randomzed into four groups, each group was 5 rabbits. Control group（group A）, general stent group（group B）, PIP targeting TGF-β1 controlled release stent （group C） and the mismatching PIP group （group D）. Animals were killed at 30 days and defined segments of ureteral were sectioned and observed about ureteral stricture degree, the expression level of TGF-β1 and a-SMA. Results There was different degree of stenosis in all four groups of ureteral lumen, however, group C was the lowest degree of stenosis（P<0.01）. The average thickness of narrow segment ureteral was 2.4±0.6 nm in group A, 2.1±0.7 nm in group B, 1.5±0.4 nm in group C and 2.2±0.4 nm in group D. Compared with the other groups, the expression levels of TGF-β1 and a-SMA were significantly lower in group C（P<0.01）. Conclusion PIP controlled-release stents which specific silencing of TGF-β1 can effectively reduce the degree of ureteral stricture occurred.

Key words: PIP, Ureteral stricture, TGF-β1