关键词: 急性非复杂性阑尾炎, 抗生素治疗, 阑尾切除术

Abstract: 【Abstract】〓Objective〓To analyze and compare the clinical effect and safety of antibiotic therapy and appendectomy for the treatment of acute uncomplicated appendicitis (AUA). Methods Patients who met the inclusion and exclusion criterions were assigned to two groups, antibiotic group (108 cases) and surgery group (111 cases). The cases in the antibiotic group received classes of antimicrobial agents plus metronidazole and the ones in the surgery groups received appendectomy and perioperative antibiotic treatment. The treatment effect was regarded as the primary outcome. The other clinical effects were compared between two groups. Results〓All the cases in the surgery group underwent successful appendectomy, leading to a success incidence of 100%. Moreover, the ones in the antibiotic group had a successful treatment incidence of 77.8% (84/108). The intention to treatment analysis yielded a difference in treatment efficacy of two groups of 22.2%, which was within the range of prespecified noninferiority margin of 24%. Hence efficacy of antibiotic treatment was similar to surgery. Moreover, the cases in the antibiotic group had favor outcomes in the fields of complications, expenses, visual analog scale (VAS) for pain feeling during hospital stay. Conclusion The patients with AUA received antibiotic treatment had a similar curative effect than the ones following appendectomy. Moreover, the AUA patients with antibiotic treatment had less pain, recovered faster and spent less.

Key words: Antibiotic treatment, Appendectomy, Acute uncomplicated appendicitis